An improved method for the synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines via palladium-catalyzed heteroannulation using microwave heating

Corey R. Hopkins, Nicola Collar

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.

Original languageEnglish (US)
Pages (from-to)8631-8633
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number47
DOIs
StatePublished - Nov 15 2004

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Pyrazines
Microwave heating
Palladium
Microwaves
Heating
Substrates

Keywords

  • 6-Substituted-5H-pyrrolo[2,3-b]pyrazine
  • Cyclization
  • Heteroannulation
  • Microwave
  • Palladium

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

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abstract = "We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.",
keywords = "6-Substituted-5H-pyrrolo[2,3-b]pyrazine, Cyclization, Heteroannulation, Microwave, Palladium",
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AU - Hopkins, Corey R.

AU - Collar, Nicola

PY - 2004/11/15

Y1 - 2004/11/15

N2 - We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.

AB - We herein report an improved synthesis of 6-substituted-5H-pyrrolo[2,3-b] pyrazines utilizing microwave heating. The reaction is a palladium-catalyzed heteroannulation process followed by deprotection to yield the desired substrates in good yield.

KW - 6-Substituted-5H-pyrrolo[2,3-b]pyrazine

KW - Cyclization

KW - Heteroannulation

KW - Microwave

KW - Palladium

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