An immunological basis of hyperphagia driven by GABAergic dysfunction in Prader-Willi Syndrome

Ujjwal Rout, Omar A. Abdul-Rahman, Dirk Marcel Dhossche

Research output: Contribution to journalArticle

3 Scopus citations


Impaired immune function is increasingly seen as a core element of various neurological, psychiatric, and developmental disorders but has not yet been investigated in subjects with Prader-Willi Syndrome. We hypothesize that the emergence and the progression of PWS may be regulated by immune dysfunction involving auto-antibodies and miRNA driven by GABAergic dysfunction. Future research testing this hypothesis is discussed.

Original languageEnglish (US)
Pages (from-to)462-464
Number of pages3
JournalMedical Hypotheses
Issue number4
StatePublished - Apr 1 2012


ASJC Scopus subject areas

  • Medicine(all)

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