### Abstract

Many developing systems obey the principle of continuity: a morphogenetic field, when perturbed, tends to restore the normal local pattern of structures in its organ district. We have investigated physical field theories for a morphogenetic field, seeking constraints which would make a field theory produce the principle of continuity. We assume that during embryonic (ontogenetic) development a leg develops a pattern of positional values and a length which extremize a time-independent functional-the integral, over the length of the leg, of a function of positional values and position. For a single state variable which represents positional value, if a unique extremizing solution for the ontogenetically generated pattern and the length exists, and if no position-dependent functions other than the state variable appear in the integrand, then the principle of continuity is valid: in any regenerated leg the state variable is continuous and each region is locally identical to a region of the ontogenetically generated leg. This proposition is applied to three simple examples. For an exponential gradient and a Jacobi elliptic function there is a set of parameter values and boundary values for which a functional is minimized and the ontogenetically generated leg has an optimal length. Thus a leg which meets these constraints will obey the principle of continuity. However, a functional which when extremized gives a sinusoidal pattern does not in general provide a unique extremal length. Mathematical conditions are discussed under which an ontogenetically generated limb or a regenerated limb represents an asymptotically stable steady state. For a specific model of the transient dynamics in the exponential gradient case, the steady state gradient is asymptotically stable.

Original language | English (US) |
---|---|

Pages (from-to) | 595-634 |

Number of pages | 40 |

Journal | Bulletin of Mathematical Biology |

Volume | 50 |

Issue number | 6 |

DOIs | |

State | Published - Nov 1 1988 |

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### ASJC Scopus subject areas

- Neuroscience(all)
- Immunology
- Mathematics(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Environmental Science(all)
- Pharmacology
- Agricultural and Biological Sciences(all)
- Computational Theory and Mathematics

### Cite this

*Bulletin of Mathematical Biology*,

*50*(6), 595-634. https://doi.org/10.1007/BF02460093

**An extremal criterion for epimorphic regeneration.** / Clarke, Bertrand S.; Mittenthal, Jay E.; Arcuri, Phillip A.

Research output: Contribution to journal › Article

*Bulletin of Mathematical Biology*, vol. 50, no. 6, pp. 595-634. https://doi.org/10.1007/BF02460093

}

TY - JOUR

T1 - An extremal criterion for epimorphic regeneration

AU - Clarke, Bertrand S.

AU - Mittenthal, Jay E.

AU - Arcuri, Phillip A.

PY - 1988/11/1

Y1 - 1988/11/1

N2 - Many developing systems obey the principle of continuity: a morphogenetic field, when perturbed, tends to restore the normal local pattern of structures in its organ district. We have investigated physical field theories for a morphogenetic field, seeking constraints which would make a field theory produce the principle of continuity. We assume that during embryonic (ontogenetic) development a leg develops a pattern of positional values and a length which extremize a time-independent functional-the integral, over the length of the leg, of a function of positional values and position. For a single state variable which represents positional value, if a unique extremizing solution for the ontogenetically generated pattern and the length exists, and if no position-dependent functions other than the state variable appear in the integrand, then the principle of continuity is valid: in any regenerated leg the state variable is continuous and each region is locally identical to a region of the ontogenetically generated leg. This proposition is applied to three simple examples. For an exponential gradient and a Jacobi elliptic function there is a set of parameter values and boundary values for which a functional is minimized and the ontogenetically generated leg has an optimal length. Thus a leg which meets these constraints will obey the principle of continuity. However, a functional which when extremized gives a sinusoidal pattern does not in general provide a unique extremal length. Mathematical conditions are discussed under which an ontogenetically generated limb or a regenerated limb represents an asymptotically stable steady state. For a specific model of the transient dynamics in the exponential gradient case, the steady state gradient is asymptotically stable.

AB - Many developing systems obey the principle of continuity: a morphogenetic field, when perturbed, tends to restore the normal local pattern of structures in its organ district. We have investigated physical field theories for a morphogenetic field, seeking constraints which would make a field theory produce the principle of continuity. We assume that during embryonic (ontogenetic) development a leg develops a pattern of positional values and a length which extremize a time-independent functional-the integral, over the length of the leg, of a function of positional values and position. For a single state variable which represents positional value, if a unique extremizing solution for the ontogenetically generated pattern and the length exists, and if no position-dependent functions other than the state variable appear in the integrand, then the principle of continuity is valid: in any regenerated leg the state variable is continuous and each region is locally identical to a region of the ontogenetically generated leg. This proposition is applied to three simple examples. For an exponential gradient and a Jacobi elliptic function there is a set of parameter values and boundary values for which a functional is minimized and the ontogenetically generated leg has an optimal length. Thus a leg which meets these constraints will obey the principle of continuity. However, a functional which when extremized gives a sinusoidal pattern does not in general provide a unique extremal length. Mathematical conditions are discussed under which an ontogenetically generated limb or a regenerated limb represents an asymptotically stable steady state. For a specific model of the transient dynamics in the exponential gradient case, the steady state gradient is asymptotically stable.

UR - http://www.scopus.com/inward/record.url?scp=0023709312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023709312&partnerID=8YFLogxK

U2 - 10.1007/BF02460093

DO - 10.1007/BF02460093

M3 - Article

C2 - 3219447

AN - SCOPUS:0023709312

VL - 50

SP - 595

EP - 634

JO - Bulletin of Mathematical Biology

JF - Bulletin of Mathematical Biology

SN - 0092-8240

IS - 6

ER -