An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons

Rafael Gongora, Robert P. Stephan, Zhixin Zhang, Max D. Cooper

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Interferon-α and -β inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors via an unknown, STAT1-independent pathway. Gene expression profile analysis of interferon-β-treated progenitor B cells revealed enhanced Daxx expression, with concomitant Daxx protein increase and nuclear body translocation. The interferon effects included downregulation of cell cycle regulating genes and cell cycle arrest, followed by Bcl-2 downregulation and apoptosis. Daxx antisense oligonucleotides rescued the interferon-treated pro-B cells from growth arrest and apoptosis in parallel with the reduction of nuclear Daxx. These findings implicate the gene repressor function of Daxx in interferon-induced apoptosis of lymphoid progenitors.

Original languageEnglish (US)
Pages (from-to)727-737
Number of pages11
JournalImmunity
Volume14
Issue number6
DOIs
StatePublished - Jan 1 2001

Fingerprint

Lymphopoiesis
Interferon Type I
Interferons
B-Lymphoid Precursor Cells
Apoptosis
Down-Regulation
cdc Genes
Interleukin-7
Antisense Oligonucleotides
Growth
Nuclear Proteins
Cell Cycle Checkpoints
Transcriptome
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons. / Gongora, Rafael; Stephan, Robert P.; Zhang, Zhixin; Cooper, Max D.

In: Immunity, Vol. 14, No. 6, 01.01.2001, p. 727-737.

Research output: Contribution to journalArticle

Gongora, Rafael ; Stephan, Robert P. ; Zhang, Zhixin ; Cooper, Max D. / An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons. In: Immunity. 2001 ; Vol. 14, No. 6. pp. 727-737.
@article{c1d4a0ac3c80473db4c2240989b29e43,
title = "An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons",
abstract = "Interferon-α and -β inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors via an unknown, STAT1-independent pathway. Gene expression profile analysis of interferon-β-treated progenitor B cells revealed enhanced Daxx expression, with concomitant Daxx protein increase and nuclear body translocation. The interferon effects included downregulation of cell cycle regulating genes and cell cycle arrest, followed by Bcl-2 downregulation and apoptosis. Daxx antisense oligonucleotides rescued the interferon-treated pro-B cells from growth arrest and apoptosis in parallel with the reduction of nuclear Daxx. These findings implicate the gene repressor function of Daxx in interferon-induced apoptosis of lymphoid progenitors.",
author = "Rafael Gongora and Stephan, {Robert P.} and Zhixin Zhang and Cooper, {Max D.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1016/S1074-7613(01)00152-2",
language = "English (US)",
volume = "14",
pages = "727--737",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons

AU - Gongora, Rafael

AU - Stephan, Robert P.

AU - Zhang, Zhixin

AU - Cooper, Max D.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Interferon-α and -β inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors via an unknown, STAT1-independent pathway. Gene expression profile analysis of interferon-β-treated progenitor B cells revealed enhanced Daxx expression, with concomitant Daxx protein increase and nuclear body translocation. The interferon effects included downregulation of cell cycle regulating genes and cell cycle arrest, followed by Bcl-2 downregulation and apoptosis. Daxx antisense oligonucleotides rescued the interferon-treated pro-B cells from growth arrest and apoptosis in parallel with the reduction of nuclear Daxx. These findings implicate the gene repressor function of Daxx in interferon-induced apoptosis of lymphoid progenitors.

AB - Interferon-α and -β inhibit the interleukin-7-mediated growth and survival of T and B lymphoid progenitors via an unknown, STAT1-independent pathway. Gene expression profile analysis of interferon-β-treated progenitor B cells revealed enhanced Daxx expression, with concomitant Daxx protein increase and nuclear body translocation. The interferon effects included downregulation of cell cycle regulating genes and cell cycle arrest, followed by Bcl-2 downregulation and apoptosis. Daxx antisense oligonucleotides rescued the interferon-treated pro-B cells from growth arrest and apoptosis in parallel with the reduction of nuclear Daxx. These findings implicate the gene repressor function of Daxx in interferon-induced apoptosis of lymphoid progenitors.

UR - http://www.scopus.com/inward/record.url?scp=0034948684&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034948684&partnerID=8YFLogxK

U2 - 10.1016/S1074-7613(01)00152-2

DO - 10.1016/S1074-7613(01)00152-2

M3 - Article

VL - 14

SP - 727

EP - 737

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 6

ER -