An enhanced thirteen-week bioassay as an alternative for screening for carcinogenesis factors

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8 Citations (Scopus)

Abstract

Utilizing basic concepts of chemical carcinogenesis and the human relevance framework based on mode of action analysis of animal carcinogens, an alternative is proposed for the two-year bioassay for screening chemicals for potential carcinogenic risk in humans. This model includes short-term screening of chemicals for DNA reactivity, immunosuppressive and, estrogenic activity, and potential increased cell proliferation. Follow-up studies can provide detailed information with regard to dose response and mode of action, with a detailed evaluation of potential relevance to humans. It is no longer appropriate to continue performing two year rodent bioassays.

Original languageEnglish (US)
Pages (from-to)15-17
Number of pages3
JournalAsian Pacific Journal of Cancer Prevention
Volume11
Issue number1
StatePublished - Jan 1 2010

Fingerprint

Biological Assay
Carcinogenesis
Chemical Phenomena
Immunosuppressive Agents
Carcinogens
Rodentia
Cell Proliferation
DNA

Keywords

  • Carcinogenesis screening
  • Cell proliferation
  • Estrogen
  • Immunosuppression
  • Two-year bioassay

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

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