An EEG analysis of convulsive activity produced by cholinergic agents

Steven L. Cohen, Barbara J. Morley, O. Carter Snead

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

1. 1. EEG activity was assessed in rats following the intraventricular injection of cholinergic agonists (carbamylcholine and nicotine tartrate), nicotinic antagonists (d-tubocurarine and α-bungarotoxin), ganglionic blockers (mecamylamine and hexamethonium), decamethonium, antibodies prepared against purified electric fish acetylcholine receptor, and human sera from myasthenic and epileptic patients. 2. 2. Seizures were produced only by agonists and nicotinic antagonists. 3. 3. Carbamylcholine produced clonic/tonic convulsions. Nicotine resulted in a depressed EEG with sporadic seizures. 4. 4. Both antagonists produced clonic/tonic seizures and spike activity. Carbamylcholine-induced seizures were blocked by scopolamine. 5. 5. No agent was found to block antagonist-induced seizures.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalProgress in Neuro-Psychopharmacology
Volume5
Issue number4
DOIs
Publication statusPublished - 1981

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Keywords

  • EEG
  • carbamylcholine
  • nicotine
  • nicotinic acetylcholine receptors
  • α-bungarotoxin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health
  • Pharmacology (medical)

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