An EEG analysis of convulsive activity produced by cholinergic agents

Steven L. Cohen, Barbara J. Morley, O. Carter Snead

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

1. 1. EEG activity was assessed in rats following the intraventricular injection of cholinergic agonists (carbamylcholine and nicotine tartrate), nicotinic antagonists (d-tubocurarine and α-bungarotoxin), ganglionic blockers (mecamylamine and hexamethonium), decamethonium, antibodies prepared against purified electric fish acetylcholine receptor, and human sera from myasthenic and epileptic patients. 2. 2. Seizures were produced only by agonists and nicotinic antagonists. 3. 3. Carbamylcholine produced clonic/tonic convulsions. Nicotine resulted in a depressed EEG with sporadic seizures. 4. 4. Both antagonists produced clonic/tonic seizures and spike activity. Carbamylcholine-induced seizures were blocked by scopolamine. 5. 5. No agent was found to block antagonist-induced seizures.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalProgress in Neuro-Psychopharmacology
Volume5
Issue number4
DOIs
StatePublished - 1981

Fingerprint

Cholinergic Agents
Electroencephalography
Seizures
Carbachol
Nicotinic Antagonists
Nicotine
Ganglionic Blockers
Electric Fish
Tonic-Clonic Epilepsy
Intraventricular Injections
Mecamylamine
Bungarotoxins
Cholinergic Agonists
Tubocurarine
Hexamethonium
Scopolamine Hydrobromide
Muscle Weakness
Cholinergic Receptors
Antibodies
Serum

Keywords

  • EEG
  • carbamylcholine
  • nicotine
  • nicotinic acetylcholine receptors
  • α-bungarotoxin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

An EEG analysis of convulsive activity produced by cholinergic agents. / Cohen, Steven L.; Morley, Barbara J.; Snead, O. Carter.

In: Progress in Neuro-Psychopharmacology, Vol. 5, No. 4, 1981, p. 383-388.

Research output: Contribution to journalArticle

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