An approach to sequence DNA without tagging

Sanjun Niu, Ravi F. Saraf

Research output: Contribution to journalConference article

Abstract

A concept to sequence DNA without tagging the molecule is developed. The fabrication process is compatible with current microelectronics and (emerging) soft-material fabrication technologies, allowing the method to be integrable with MEMS and lab-on-a-chip devices. The preliminary results indicate sensitivity in the nano-gram regime for 100 micron-square pixels. The technology can be extended to perform combinatorial analysis with on-line measurement in real-time during the hybridization process.

Original languageEnglish (US)
Pages (from-to)246-254
Number of pages9
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4512
DOIs
StatePublished - Dec 1 2001
EventComplex Adaptive Structures - Hutchinson Island, FL, United States
Duration: Jun 4 2001Jun 6 2001

Fingerprint

DNA sequences
Tagging
DNA Sequence
marking
Fabrication
combinatorial analysis
deoxyribonucleic acid
lab-on-a-chip devices
Lab-on-a-chip
Combinatorial Analysis
fabrication
Micro-electro-mechanical Systems
microelectronics
Microelectronics
microelectromechanical systems
MEMS
emerging
Pixel
Pixels
pixels

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

An approach to sequence DNA without tagging. / Niu, Sanjun; Saraf, Ravi F.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 4512, 01.12.2001, p. 246-254.

Research output: Contribution to journalConference article

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