An adjunct mammary epithelial cell population in parous females

Its role in functional adaptation and tissue renewal

Kay-Uwe Wagner, Corinne A. Boulanger, Ma Linda D. Henry, Magdalene Sgagias, Lothar Hennighausen, Gilbert H. Smith

Research output: Contribution to journalArticle

209 Citations (Scopus)

Abstract

Mammary gland biologists have long assumed that differentiated secretory epithelial cells undergo programmed cell death at the end of lactation and that the alveolar compartment is reconstituted from undifferentiated precursor cells in subsequent pregnancies. It is generally agreed that the remodeled gland in a parous animal resembles that of a mature virgin at the morphological level. However, several physiological differences have been noted in comparing the responses of mammary epithelia from nulliparous versus parous females to hormonal stimulation and carcinogenic agents. We present genetic evidence that an involuted mammary gland is fundamentally different from a virgin gland, despite its close morphological resemblance. This difference results from the formation of a new mammary epithelial cell population that originates from differentiating cells during pregnancy. In contrast to the majority of fully committed alveolar cells, this epithelial population does not undergo cell death during involution or remodeling after lactation. We show that these cells can function as alveolar progenitors in subsequent pregnancies and that they can play an important role in functional adaptation in genetically engineered mice, which exhibit a reversion of a lactation-deficient phenotype in multiparous animals. In transplantation studies, this parity-induced epithelial population shows the capacity for self-renewal and contributes significantly to the reconstitution of the resulting mammary outgrowth (i.e. ductal morphogenesis and lobulogenesis). We propose that this parity-induced population contributes importantly to the biological differences between the mammary glands of parous and nulliparous females.

Original languageEnglish (US)
Pages (from-to)1377-1386
Number of pages10
JournalDevelopment
Volume129
Issue number6
StatePublished - Aug 23 2002

Fingerprint

Breast
Human Mammary Glands
Epithelial Cells
Lactation
Parity
Pregnancy
Population
Cell Death
Alveolar Epithelial Cells
Morphogenesis
Epithelium
Transplantation
Phenotype

Keywords

  • Cre recombinase
  • Differentiation
  • Epithelium
  • Involution
  • Mammary gland
  • Mouse
  • Parity
  • Stem cells

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Cite this

Wagner, K-U., Boulanger, C. A., Henry, M. L. D., Sgagias, M., Hennighausen, L., & Smith, G. H. (2002). An adjunct mammary epithelial cell population in parous females: Its role in functional adaptation and tissue renewal. Development, 129(6), 1377-1386.

An adjunct mammary epithelial cell population in parous females : Its role in functional adaptation and tissue renewal. / Wagner, Kay-Uwe; Boulanger, Corinne A.; Henry, Ma Linda D.; Sgagias, Magdalene; Hennighausen, Lothar; Smith, Gilbert H.

In: Development, Vol. 129, No. 6, 23.08.2002, p. 1377-1386.

Research output: Contribution to journalArticle

Wagner, K-U, Boulanger, CA, Henry, MLD, Sgagias, M, Hennighausen, L & Smith, GH 2002, 'An adjunct mammary epithelial cell population in parous females: Its role in functional adaptation and tissue renewal', Development, vol. 129, no. 6, pp. 1377-1386.
Wagner K-U, Boulanger CA, Henry MLD, Sgagias M, Hennighausen L, Smith GH. An adjunct mammary epithelial cell population in parous females: Its role in functional adaptation and tissue renewal. Development. 2002 Aug 23;129(6):1377-1386.
Wagner, Kay-Uwe ; Boulanger, Corinne A. ; Henry, Ma Linda D. ; Sgagias, Magdalene ; Hennighausen, Lothar ; Smith, Gilbert H. / An adjunct mammary epithelial cell population in parous females : Its role in functional adaptation and tissue renewal. In: Development. 2002 ; Vol. 129, No. 6. pp. 1377-1386.
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