Amyloidosis complicating hairy cell leukemia

James Linder, H. R. Silberman, B. P. Croker

Research output: Contribution to journalArticle

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Abstract

A patient developed renal failure following a ten-year affliction with hairy cell leukemia. Renal biopsy showed amyloidosis, characterized by the presence of potassium permagnate-sensitive congophilia in deposits within glomeruli and renal blood vessels. Electron microscopy demonstrated amyloid fibrils. Immunohistochemical technics showed the deposits were composed of AA Protein. These Congo red staining properties, and the presence of AA Protein are characteristic of deposits in secondary amyloidosis. Secondary amyloidosis is a known complication of many chronic illnesses. This report shows it may concur with hairy cell leukemia, and that amyloidosis should be considered in the differential diagnosis of renal failure in patients with hairy cell leukemia.

Original languageEnglish (US)
Pages (from-to)864-867
Number of pages4
JournalAmerican journal of clinical pathology
Volume78
Issue number6
DOIs
StatePublished - Jan 1 1982

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Hairy Cell Leukemia
Amyloidosis
Renal Insufficiency
Kidney
Congo Red
Amyloid
Blood Vessels
Electron Microscopy
Potassium
Proteins
Differential Diagnosis
Chronic Disease
Staining and Labeling
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Amyloidosis complicating hairy cell leukemia. / Linder, James; Silberman, H. R.; Croker, B. P.

In: American journal of clinical pathology, Vol. 78, No. 6, 01.01.1982, p. 864-867.

Research output: Contribution to journalArticle

Linder, James ; Silberman, H. R. ; Croker, B. P. / Amyloidosis complicating hairy cell leukemia. In: American journal of clinical pathology. 1982 ; Vol. 78, No. 6. pp. 864-867.
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