Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Poomy Pandey, Bailee Sliker, Haley L. Peters, Amit Tuli, Jonathan Herskovitz, Kaitlin Smits, Abhilasha Purohit, Rakesh K Singh, Jixin Dong, Surinder Kumar Batra, Donald W Coulter, Joyce C Solheim

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.

Original languageEnglish (US)
Pages (from-to)19430-19444
Number of pages15
JournalOncotarget
Volume7
Issue number15
DOIs
StatePublished - Apr 12 2016

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Keywords

  • Amyloid precursor protein
  • Amyloid precursor-like protein 2
  • Cancer
  • Growth
  • Migration

ASJC Scopus subject areas

  • Oncology

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