Abstract

Amyloid precursor-like protein 2 (APLP2) is aberrantly expressed in pancreatic cancer. Here we showed that APLP2 is increased in pancreatic cancer metastases, particularly in metastatic lesions found in the diaphragm and intestine. Examination of matched human primary tumor-liver metastasis pairs showed that 38.1% of the patients had positive APLP2 expression in both the primary tumor and the corresponding liver metastasis. Stable knock-down of APLP2 expression (with inducible shRNA) in pancreatic cancer cells reduced the ability of these cells to migrate and invade. Loss of APLP2 decreased cortical actin and increased intracellular actin filaments in pancreatic cancer cells. Down-regulation of APLP2 decreased the weight and metastasis of orthotopically transplanted pancreatic tumors in nude mice.

Original languageEnglish (US)
Pages (from-to)2064-2075
Number of pages12
JournalOncotarget
Volume6
Issue number4
DOIs
StatePublished - Jan 1 2015

Fingerprint

Amyloid beta-Protein Precursor
Actin Cytoskeleton
Pancreatic Neoplasms
Neoplasm Metastasis
Growth
Neoplasms
Liver
Diaphragm
Nude Mice
Small Interfering RNA
Intestines
Actins
Down-Regulation
Weights and Measures

Keywords

  • Actin
  • Amyloid precursor-like protein 2
  • Metastasis
  • Migration
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology

Cite this

Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis. / Pandey, Poomy; Rachagani, Satyanarayana; Das, Srustidhar; Seshacharyulu, Parthasarathy; Sheinin, Yuri; Naslavsky, Naava; Pan, Zenggang; Smith, Brittney L.; Peters, Haley L.; Radhakrishnan, Prakash; McKenna, Nicole R.; Panapakkam Giridharan, Sai Srinivas; Haridas, Dhanya; Kaur, Sukwinder; Hollingsworth, Michael A; MacDonald, Richard G; Meza, Jane L; Caplan, Steven H; Batra, Surinder Kumar; Solheim, Joyce C.

In: Oncotarget, Vol. 6, No. 4, 01.01.2015, p. 2064-2075.

Research output: Contribution to journalArticle

Pandey, Poomy ; Rachagani, Satyanarayana ; Das, Srustidhar ; Seshacharyulu, Parthasarathy ; Sheinin, Yuri ; Naslavsky, Naava ; Pan, Zenggang ; Smith, Brittney L. ; Peters, Haley L. ; Radhakrishnan, Prakash ; McKenna, Nicole R. ; Panapakkam Giridharan, Sai Srinivas ; Haridas, Dhanya ; Kaur, Sukwinder ; Hollingsworth, Michael A ; MacDonald, Richard G ; Meza, Jane L ; Caplan, Steven H ; Batra, Surinder Kumar ; Solheim, Joyce C. / Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis. In: Oncotarget. 2015 ; Vol. 6, No. 4. pp. 2064-2075.
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