Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety

Amanda E. Guyer, Jennifer Y.F. Lau, Erin B. McClure-Tone, Jessica Parrish, Nina D. Shiffrin, Richard C. Reynolds, Gang Chen, R. J.R. Blair, Ellen Leibenluft, Nathan A. Fox, Monique Ernst, Daniel S. Pine, Eric E. Nelson

Research output: Contribution to journalArticle

218 Citations (Scopus)

Abstract

Context: Amygdala and ventrolateral prefrontal cortex (vlPFC) dysfunction manifests in adolescents with anxiety disorders when they view negatively valenced stimuli in threatening contexts. Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening. Objective: To determine whether photographs of negatively evaluated smiling peers viewed during anticipated social evaluation engage the amygdala and vlPFC differentially in adolescents with and without social anxiety. Design: Case-control study. Setting: Government clinical research institute. Participants: Fourteen adolescents with anxiety disorders associated with marked concerns of social evaluation and 14 adolescents without a psychiatric diagnosis matched on sex, age, intelligence quotient, and socioeconomic status. Main Outcome Measures: Blood oxygenation level-dependent signal measured with event-related functional magnetic resonance imaging. Before and during neuroimaging scans, participants anticipating social evaluation completed peer- and self-appraisals. Event-related analyses were tailored to participants' ratings of specific peers. Results: Participants classified 40 pictures of same-age peers as ones with whom they did or did not want to engage in a social interaction. Anxious adolescents showed greater amygdala activation than healthy adolescents when anticipating evaluation from peers previously rated as undesired for an interaction. Psychophysiological interaction connectivity analyses also revealed a significant positive association between amygdala and vlPFC activation in anxious vs healthy adolescents in response to these stimuli. Conclusions: Anticipating social evaluation from negatively perceived peers modulates amygdala and vlPFC engagement differentially in anxious and healthy adolescents. Amygdala and vlPFC dysfunction manifests in adolescent anxiety disorders in specific contexts of anticipated peer evaluation.

Original languageEnglish (US)
Pages (from-to)1303-1312
Number of pages10
JournalArchives of general psychiatry
Volume65
Issue number11
DOIs
StatePublished - Nov 1 2008

Fingerprint

Amygdala
Prefrontal Cortex
Anxiety
Pediatrics
Anxiety Disorders
Peer Evaluation
Smiling
Diagnostic Self Evaluation
Interpersonal Relations
Intelligence
Mental Disorders
Neuroimaging
Social Class
Fear
Peers
Case-Control Studies
Magnetic Resonance Imaging
Outcome Assessment (Health Care)
Evaluation

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Guyer, A. E., Lau, J. Y. F., McClure-Tone, E. B., Parrish, J., Shiffrin, N. D., Reynolds, R. C., ... Nelson, E. E. (2008). Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety. Archives of general psychiatry, 65(11), 1303-1312. https://doi.org/10.1001/archpsyc.65.11.1303

Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety. / Guyer, Amanda E.; Lau, Jennifer Y.F.; McClure-Tone, Erin B.; Parrish, Jessica; Shiffrin, Nina D.; Reynolds, Richard C.; Chen, Gang; Blair, R. J.R.; Leibenluft, Ellen; Fox, Nathan A.; Ernst, Monique; Pine, Daniel S.; Nelson, Eric E.

In: Archives of general psychiatry, Vol. 65, No. 11, 01.11.2008, p. 1303-1312.

Research output: Contribution to journalArticle

Guyer, AE, Lau, JYF, McClure-Tone, EB, Parrish, J, Shiffrin, ND, Reynolds, RC, Chen, G, Blair, RJR, Leibenluft, E, Fox, NA, Ernst, M, Pine, DS & Nelson, EE 2008, 'Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety', Archives of general psychiatry, vol. 65, no. 11, pp. 1303-1312. https://doi.org/10.1001/archpsyc.65.11.1303
Guyer, Amanda E. ; Lau, Jennifer Y.F. ; McClure-Tone, Erin B. ; Parrish, Jessica ; Shiffrin, Nina D. ; Reynolds, Richard C. ; Chen, Gang ; Blair, R. J.R. ; Leibenluft, Ellen ; Fox, Nathan A. ; Ernst, Monique ; Pine, Daniel S. ; Nelson, Eric E. / Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety. In: Archives of general psychiatry. 2008 ; Vol. 65, No. 11. pp. 1303-1312.
@article{c5ea9cc7f36145588b5b8a4433eea619,
title = "Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety",
abstract = "Context: Amygdala and ventrolateral prefrontal cortex (vlPFC) dysfunction manifests in adolescents with anxiety disorders when they view negatively valenced stimuli in threatening contexts. Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening. Objective: To determine whether photographs of negatively evaluated smiling peers viewed during anticipated social evaluation engage the amygdala and vlPFC differentially in adolescents with and without social anxiety. Design: Case-control study. Setting: Government clinical research institute. Participants: Fourteen adolescents with anxiety disorders associated with marked concerns of social evaluation and 14 adolescents without a psychiatric diagnosis matched on sex, age, intelligence quotient, and socioeconomic status. Main Outcome Measures: Blood oxygenation level-dependent signal measured with event-related functional magnetic resonance imaging. Before and during neuroimaging scans, participants anticipating social evaluation completed peer- and self-appraisals. Event-related analyses were tailored to participants' ratings of specific peers. Results: Participants classified 40 pictures of same-age peers as ones with whom they did or did not want to engage in a social interaction. Anxious adolescents showed greater amygdala activation than healthy adolescents when anticipating evaluation from peers previously rated as undesired for an interaction. Psychophysiological interaction connectivity analyses also revealed a significant positive association between amygdala and vlPFC activation in anxious vs healthy adolescents in response to these stimuli. Conclusions: Anticipating social evaluation from negatively perceived peers modulates amygdala and vlPFC engagement differentially in anxious and healthy adolescents. Amygdala and vlPFC dysfunction manifests in adolescent anxiety disorders in specific contexts of anticipated peer evaluation.",
author = "Guyer, {Amanda E.} and Lau, {Jennifer Y.F.} and McClure-Tone, {Erin B.} and Jessica Parrish and Shiffrin, {Nina D.} and Reynolds, {Richard C.} and Gang Chen and Blair, {R. J.R.} and Ellen Leibenluft and Fox, {Nathan A.} and Monique Ernst and Pine, {Daniel S.} and Nelson, {Eric E.}",
year = "2008",
month = "11",
day = "1",
doi = "10.1001/archpsyc.65.11.1303",
language = "English (US)",
volume = "65",
pages = "1303--1312",
journal = "JAMA Psychiatry",
issn = "2168-622X",
publisher = "American Medical Association",
number = "11",

}

TY - JOUR

T1 - Amygdala and ventrolateral prefrontal cortex function during anticipated peer evaluation in pediatric social anxiety

AU - Guyer, Amanda E.

AU - Lau, Jennifer Y.F.

AU - McClure-Tone, Erin B.

AU - Parrish, Jessica

AU - Shiffrin, Nina D.

AU - Reynolds, Richard C.

AU - Chen, Gang

AU - Blair, R. J.R.

AU - Leibenluft, Ellen

AU - Fox, Nathan A.

AU - Ernst, Monique

AU - Pine, Daniel S.

AU - Nelson, Eric E.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Context: Amygdala and ventrolateral prefrontal cortex (vlPFC) dysfunction manifests in adolescents with anxiety disorders when they view negatively valenced stimuli in threatening contexts. Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening. Objective: To determine whether photographs of negatively evaluated smiling peers viewed during anticipated social evaluation engage the amygdala and vlPFC differentially in adolescents with and without social anxiety. Design: Case-control study. Setting: Government clinical research institute. Participants: Fourteen adolescents with anxiety disorders associated with marked concerns of social evaluation and 14 adolescents without a psychiatric diagnosis matched on sex, age, intelligence quotient, and socioeconomic status. Main Outcome Measures: Blood oxygenation level-dependent signal measured with event-related functional magnetic resonance imaging. Before and during neuroimaging scans, participants anticipating social evaluation completed peer- and self-appraisals. Event-related analyses were tailored to participants' ratings of specific peers. Results: Participants classified 40 pictures of same-age peers as ones with whom they did or did not want to engage in a social interaction. Anxious adolescents showed greater amygdala activation than healthy adolescents when anticipating evaluation from peers previously rated as undesired for an interaction. Psychophysiological interaction connectivity analyses also revealed a significant positive association between amygdala and vlPFC activation in anxious vs healthy adolescents in response to these stimuli. Conclusions: Anticipating social evaluation from negatively perceived peers modulates amygdala and vlPFC engagement differentially in anxious and healthy adolescents. Amygdala and vlPFC dysfunction manifests in adolescent anxiety disorders in specific contexts of anticipated peer evaluation.

AB - Context: Amygdala and ventrolateral prefrontal cortex (vlPFC) dysfunction manifests in adolescents with anxiety disorders when they view negatively valenced stimuli in threatening contexts. Such fear-circuitry dysfunction may also manifest when anticipated social evaluation leads socially anxious adolescents to misperceive peers as threatening. Objective: To determine whether photographs of negatively evaluated smiling peers viewed during anticipated social evaluation engage the amygdala and vlPFC differentially in adolescents with and without social anxiety. Design: Case-control study. Setting: Government clinical research institute. Participants: Fourteen adolescents with anxiety disorders associated with marked concerns of social evaluation and 14 adolescents without a psychiatric diagnosis matched on sex, age, intelligence quotient, and socioeconomic status. Main Outcome Measures: Blood oxygenation level-dependent signal measured with event-related functional magnetic resonance imaging. Before and during neuroimaging scans, participants anticipating social evaluation completed peer- and self-appraisals. Event-related analyses were tailored to participants' ratings of specific peers. Results: Participants classified 40 pictures of same-age peers as ones with whom they did or did not want to engage in a social interaction. Anxious adolescents showed greater amygdala activation than healthy adolescents when anticipating evaluation from peers previously rated as undesired for an interaction. Psychophysiological interaction connectivity analyses also revealed a significant positive association between amygdala and vlPFC activation in anxious vs healthy adolescents in response to these stimuli. Conclusions: Anticipating social evaluation from negatively perceived peers modulates amygdala and vlPFC engagement differentially in anxious and healthy adolescents. Amygdala and vlPFC dysfunction manifests in adolescent anxiety disorders in specific contexts of anticipated peer evaluation.

UR - http://www.scopus.com/inward/record.url?scp=55749114253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55749114253&partnerID=8YFLogxK

U2 - 10.1001/archpsyc.65.11.1303

DO - 10.1001/archpsyc.65.11.1303

M3 - Article

C2 - 18981342

AN - SCOPUS:55749114253

VL - 65

SP - 1303

EP - 1312

JO - JAMA Psychiatry

JF - JAMA Psychiatry

SN - 2168-622X

IS - 11

ER -