Amplitude-integrated EEG and range-EEG modulation associated with pneumatic orocutaneous stimulation in preterm infants

S. M. Barlow, P. Jegatheesan, S. Weiss, B. Govindaswami, J. Wang, J. Lee, A. Oder, D. Song

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective:Controlled somatosensory stimulation strategies have demonstrated merit in developing oral feeding skills in premature infants who lack a functional suck, however, the effects of orosensory entrainment stimulation on electrocortical dynamics is unknown. The objective of the study was to determine the effects of servo-controlled pneumatic orocutaneous stimulation presented during gavage feedings on the modulation of amplitude-integrated electroencephalogram (aEEG) and range electroencephalogram (rEEG) activity.Study Design:Two-channel EEG recordings were collected during 180 sessions that included orocutaneous stimulation and non-stimulation epochs among 22 preterm infants (mean gestational age=28.56 weeks) who were randomized to treatment and control 'sham' conditions. The study was initiated at around 32 weeks post-menstrual age. The raw EEG was transformed into aEEG margins, and rEEG amplitude bands measured at 1-min intervals and subjected to a mixed models statistical analysis.Result:Multiple significant effects were observed in the processed EEG during and immediately following 3-min periods of orocutaneous stimulation, including modulation of the upper and lower margins of the aEEG, and a reorganization of rEEG with an apparent shift from amplitude bands D and E to band C throughout the 23-min recording period that followed the first stimulus block when compared with the sham condition. Cortical asymmetry also was apparent in both EEG measures.Conclusion:Orocutaneous stimulation represents a salient trigeminal input, which has both short- and long-term effects in modulating electrocortical activity, and thus is hypothesized to represent a form of neural adaptation or plasticity that may benefit the preterm infant during this critical period of brain maturation.

Original languageEnglish (US)
Pages (from-to)213-219
Number of pages7
JournalJournal of Perinatology
Volume34
Issue number3
DOIs
StatePublished - Mar 1 2014

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Premature Infants
Electroencephalography
Statistical Models
Gestational Age
Placebos
Brain

Keywords

  • brain
  • electroencephalography
  • experience dependent
  • orofacial
  • prematurity
  • somatosensory

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Amplitude-integrated EEG and range-EEG modulation associated with pneumatic orocutaneous stimulation in preterm infants. / Barlow, S. M.; Jegatheesan, P.; Weiss, S.; Govindaswami, B.; Wang, J.; Lee, J.; Oder, A.; Song, D.

In: Journal of Perinatology, Vol. 34, No. 3, 01.03.2014, p. 213-219.

Research output: Contribution to journalArticle

Barlow, S. M. ; Jegatheesan, P. ; Weiss, S. ; Govindaswami, B. ; Wang, J. ; Lee, J. ; Oder, A. ; Song, D. / Amplitude-integrated EEG and range-EEG modulation associated with pneumatic orocutaneous stimulation in preterm infants. In: Journal of Perinatology. 2014 ; Vol. 34, No. 3. pp. 213-219.
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