Amplification of the c-myc oncogene in human plasma-cell leukemia

Janos Sumegi, T. Hedberg, M. Bjorkholm, T. Godal, H. Mellstedt, M. G. Nilsson, C. Perlman, G. Klein

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36 Citations (Scopus)

Abstract

We have examined primary leukemia cells from multiple myeloma and plasma-cell leukemia patients for rearrangement, amplification and expression of c-myc oncogene. No rearrangement or detectable amplification of the c-myc could be found in 21 cases of multiple myeloma. In contrast, 2/3 cases of plasma-cell leukemia showed amplification of the oncogene with concomitant higher level of expression.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalInternational Journal of Cancer
Volume36
Issue number3
StatePublished - Dec 1 1985

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Plasma Cell Leukemia
myc Genes
Multiple Myeloma
Oncogenes
Leukemia

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sumegi, J., Hedberg, T., Bjorkholm, M., Godal, T., Mellstedt, H., Nilsson, M. G., ... Klein, G. (1985). Amplification of the c-myc oncogene in human plasma-cell leukemia. International Journal of Cancer, 36(3), 367-371.

Amplification of the c-myc oncogene in human plasma-cell leukemia. / Sumegi, Janos; Hedberg, T.; Bjorkholm, M.; Godal, T.; Mellstedt, H.; Nilsson, M. G.; Perlman, C.; Klein, G.

In: International Journal of Cancer, Vol. 36, No. 3, 01.12.1985, p. 367-371.

Research output: Contribution to journalArticle

Sumegi, J, Hedberg, T, Bjorkholm, M, Godal, T, Mellstedt, H, Nilsson, MG, Perlman, C & Klein, G 1985, 'Amplification of the c-myc oncogene in human plasma-cell leukemia', International Journal of Cancer, vol. 36, no. 3, pp. 367-371.
Sumegi J, Hedberg T, Bjorkholm M, Godal T, Mellstedt H, Nilsson MG et al. Amplification of the c-myc oncogene in human plasma-cell leukemia. International Journal of Cancer. 1985 Dec 1;36(3):367-371.
Sumegi, Janos ; Hedberg, T. ; Bjorkholm, M. ; Godal, T. ; Mellstedt, H. ; Nilsson, M. G. ; Perlman, C. ; Klein, G. / Amplification of the c-myc oncogene in human plasma-cell leukemia. In: International Journal of Cancer. 1985 ; Vol. 36, No. 3. pp. 367-371.
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