Amplification of the c-myc oncogene in human plasma-cell leukemia

J. Sumegi, T. Hedberg, M. Bjorkholm, T. Godal, H. Mellstedt, M. G. Nilsson, C. Perlman, G. Klein

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Abstract

We have examined primary leukemia cells from multiple myeloma and plasma-cell leukemia patients for rearrangement, amplification and expression of c-myc oncogene. No rearrangement or detectable amplification of the c-myc could be found in 21 cases of multiple myeloma. In contrast, 2/3 cases of plasma-cell leukemia showed amplification of the oncogene with concomitant higher level of expression.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalInternational Journal of Cancer
Volume36
Issue number3
Publication statusPublished - Dec 1 1985

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sumegi, J., Hedberg, T., Bjorkholm, M., Godal, T., Mellstedt, H., Nilsson, M. G., ... Klein, G. (1985). Amplification of the c-myc oncogene in human plasma-cell leukemia. International Journal of Cancer, 36(3), 367-371.