Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers

Erik Letko, Stephen U. Stechschulte, Kenneth R. Kenyon, Nadia Sadeq, Tatiana R. Romero, C. Michael Samson, Quan Dong Nguyen, Stephanie L. Harper, Jonathan D. Primack, Dimitri T. Azar, Martin Gruterich, Claes H. Dohlman, Stefanos Baltatzis, C. Stephen Foster

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Objectives: To determine the effect of amniotic membrane transplantation (AMT) on persistent corneal epithelial defects (PEDs) and to compare the efficacy between inlay and overlay techniques. Methods: Thirty patients (30 eyes) underwent AMT for PED. The use of AMT was restricted to patients in whom all previous measures, including bandage contact lens and tarsorrhaphy, had failed. The amniotic membrane was placed on the surface of the cornea in overlay (group A) or inlay (group B) fashion. Results: The PED healed after the first AMT in 21 eyes (70%) within an average of 25.5 days after surgery and recurred in 6 eyes (29%). Among the 22 eyes treated with an overlay AMT (group A), the PED healed after the first AMT in 14 eyes (64%) within an average of 24.5 days and recurred in 4 eyes (29%). Among the 8 eyes treated with an inlay AMT (group B), the PED healed within an average of 27.4 days after AMT, which did not statistically significantly differ from group A (P = .72). The PED healed after the first AMT in 7 eyes (88%) and recurred in 2 (29%) of 7 eyes. Conclusions: The AMT can be helpful in the treatment of PED in which all other conventional management has failed. However, the success rate in our study was not as high as that previously reported, and our results showed a high incidence of recurrences of epithelial defects. We did not find any difference between overlay and inlay techniques in terms of healing time and recurrence rate.

Original languageEnglish (US)
Pages (from-to)659-663
Number of pages5
JournalArchives of Ophthalmology
Volume119
Issue number5
DOIs
StatePublished - Jan 1 2001

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Inlays
Amnion
Corneal Transplantation
Ulcer
Transplantation
Recurrence
Contact Lenses
Bandages
Ambulatory Surgical Procedures
Cornea

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Letko, E., Stechschulte, S. U., Kenyon, K. R., Sadeq, N., Romero, T. R., Samson, C. M., ... Foster, C. S. (2001). Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers. Archives of Ophthalmology, 119(5), 659-663. https://doi.org/10.1001/archopht.119.5.659

Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers. / Letko, Erik; Stechschulte, Stephen U.; Kenyon, Kenneth R.; Sadeq, Nadia; Romero, Tatiana R.; Samson, C. Michael; Nguyen, Quan Dong; Harper, Stephanie L.; Primack, Jonathan D.; Azar, Dimitri T.; Gruterich, Martin; Dohlman, Claes H.; Baltatzis, Stefanos; Foster, C. Stephen.

In: Archives of Ophthalmology, Vol. 119, No. 5, 01.01.2001, p. 659-663.

Research output: Contribution to journalArticle

Letko, E, Stechschulte, SU, Kenyon, KR, Sadeq, N, Romero, TR, Samson, CM, Nguyen, QD, Harper, SL, Primack, JD, Azar, DT, Gruterich, M, Dohlman, CH, Baltatzis, S & Foster, CS 2001, 'Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers', Archives of Ophthalmology, vol. 119, no. 5, pp. 659-663. https://doi.org/10.1001/archopht.119.5.659
Letko, Erik ; Stechschulte, Stephen U. ; Kenyon, Kenneth R. ; Sadeq, Nadia ; Romero, Tatiana R. ; Samson, C. Michael ; Nguyen, Quan Dong ; Harper, Stephanie L. ; Primack, Jonathan D. ; Azar, Dimitri T. ; Gruterich, Martin ; Dohlman, Claes H. ; Baltatzis, Stefanos ; Foster, C. Stephen. / Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers. In: Archives of Ophthalmology. 2001 ; Vol. 119, No. 5. pp. 659-663.
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abstract = "Objectives: To determine the effect of amniotic membrane transplantation (AMT) on persistent corneal epithelial defects (PEDs) and to compare the efficacy between inlay and overlay techniques. Methods: Thirty patients (30 eyes) underwent AMT for PED. The use of AMT was restricted to patients in whom all previous measures, including bandage contact lens and tarsorrhaphy, had failed. The amniotic membrane was placed on the surface of the cornea in overlay (group A) or inlay (group B) fashion. Results: The PED healed after the first AMT in 21 eyes (70{\%}) within an average of 25.5 days after surgery and recurred in 6 eyes (29{\%}). Among the 22 eyes treated with an overlay AMT (group A), the PED healed after the first AMT in 14 eyes (64{\%}) within an average of 24.5 days and recurred in 4 eyes (29{\%}). Among the 8 eyes treated with an inlay AMT (group B), the PED healed within an average of 27.4 days after AMT, which did not statistically significantly differ from group A (P = .72). The PED healed after the first AMT in 7 eyes (88{\%}) and recurred in 2 (29{\%}) of 7 eyes. Conclusions: The AMT can be helpful in the treatment of PED in which all other conventional management has failed. However, the success rate in our study was not as high as that previously reported, and our results showed a high incidence of recurrences of epithelial defects. We did not find any difference between overlay and inlay techniques in terms of healing time and recurrence rate.",
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T1 - Amniotic membrane inlay and overlay grafting for corneal epithelial defects and stromal ulcers

AU - Letko, Erik

AU - Stechschulte, Stephen U.

AU - Kenyon, Kenneth R.

AU - Sadeq, Nadia

AU - Romero, Tatiana R.

AU - Samson, C. Michael

AU - Nguyen, Quan Dong

AU - Harper, Stephanie L.

AU - Primack, Jonathan D.

AU - Azar, Dimitri T.

AU - Gruterich, Martin

AU - Dohlman, Claes H.

AU - Baltatzis, Stefanos

AU - Foster, C. Stephen

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N2 - Objectives: To determine the effect of amniotic membrane transplantation (AMT) on persistent corneal epithelial defects (PEDs) and to compare the efficacy between inlay and overlay techniques. Methods: Thirty patients (30 eyes) underwent AMT for PED. The use of AMT was restricted to patients in whom all previous measures, including bandage contact lens and tarsorrhaphy, had failed. The amniotic membrane was placed on the surface of the cornea in overlay (group A) or inlay (group B) fashion. Results: The PED healed after the first AMT in 21 eyes (70%) within an average of 25.5 days after surgery and recurred in 6 eyes (29%). Among the 22 eyes treated with an overlay AMT (group A), the PED healed after the first AMT in 14 eyes (64%) within an average of 24.5 days and recurred in 4 eyes (29%). Among the 8 eyes treated with an inlay AMT (group B), the PED healed within an average of 27.4 days after AMT, which did not statistically significantly differ from group A (P = .72). The PED healed after the first AMT in 7 eyes (88%) and recurred in 2 (29%) of 7 eyes. Conclusions: The AMT can be helpful in the treatment of PED in which all other conventional management has failed. However, the success rate in our study was not as high as that previously reported, and our results showed a high incidence of recurrences of epithelial defects. We did not find any difference between overlay and inlay techniques in terms of healing time and recurrence rate.

AB - Objectives: To determine the effect of amniotic membrane transplantation (AMT) on persistent corneal epithelial defects (PEDs) and to compare the efficacy between inlay and overlay techniques. Methods: Thirty patients (30 eyes) underwent AMT for PED. The use of AMT was restricted to patients in whom all previous measures, including bandage contact lens and tarsorrhaphy, had failed. The amniotic membrane was placed on the surface of the cornea in overlay (group A) or inlay (group B) fashion. Results: The PED healed after the first AMT in 21 eyes (70%) within an average of 25.5 days after surgery and recurred in 6 eyes (29%). Among the 22 eyes treated with an overlay AMT (group A), the PED healed after the first AMT in 14 eyes (64%) within an average of 24.5 days and recurred in 4 eyes (29%). Among the 8 eyes treated with an inlay AMT (group B), the PED healed within an average of 27.4 days after AMT, which did not statistically significantly differ from group A (P = .72). The PED healed after the first AMT in 7 eyes (88%) and recurred in 2 (29%) of 7 eyes. Conclusions: The AMT can be helpful in the treatment of PED in which all other conventional management has failed. However, the success rate in our study was not as high as that previously reported, and our results showed a high incidence of recurrences of epithelial defects. We did not find any difference between overlay and inlay techniques in terms of healing time and recurrence rate.

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