Amino Acids in Milk in Cystinuria

Jonathan C. Allen, Margaret C. Neville, Joy M. Seacat, Clare E. Casey, Marianne R. Neifert, William A. Gahl, William B. Rizzo

Research output: Contribution to journalLetter

Abstract

To the Editor: In a letter in the December 1 issue, Gahl and Rizzo conclude that “cystinuric breast duct epithelium apparently does not express the dibasic amino acid-transport defect characteristic of renal tubular and intestinal cells.”1 The data presented are not sufficient to support such a conclusion. There are several fundamental differences between mammary epithelia and renal tubular or intestinal epithelia. Mammary transport systems move substrates from serosa to mucosa in order to secrete milk. Renal tubular cells may transport substrate in either direction, depending on the substrate or the location in the tubule. The dibasic-amino acid transport system moves.

Original languageEnglish (US)
Pages (from-to)1332-1333
Number of pages2
JournalNew England Journal of Medicine
Volume310
Issue number20
DOIs
StatePublished - May 17 1984

Fingerprint

Cystinuria
Diamino Amino Acids
Milk
Breast
Kidney
Amino Acids
Epithelium
Amino Acid Transport Systems
Serous Membrane
Intestinal Mucosa
Mucous Membrane

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Allen, J. C., Neville, M. C., Seacat, J. M., Casey, C. E., Neifert, M. R., Gahl, W. A., & Rizzo, W. B. (1984). Amino Acids in Milk in Cystinuria. New England Journal of Medicine, 310(20), 1332-1333. https://doi.org/10.1056/NEJM198405173102020

Amino Acids in Milk in Cystinuria. / Allen, Jonathan C.; Neville, Margaret C.; Seacat, Joy M.; Casey, Clare E.; Neifert, Marianne R.; Gahl, William A.; Rizzo, William B.

In: New England Journal of Medicine, Vol. 310, No. 20, 17.05.1984, p. 1332-1333.

Research output: Contribution to journalLetter

Allen, JC, Neville, MC, Seacat, JM, Casey, CE, Neifert, MR, Gahl, WA & Rizzo, WB 1984, 'Amino Acids in Milk in Cystinuria', New England Journal of Medicine, vol. 310, no. 20, pp. 1332-1333. https://doi.org/10.1056/NEJM198405173102020
Allen JC, Neville MC, Seacat JM, Casey CE, Neifert MR, Gahl WA et al. Amino Acids in Milk in Cystinuria. New England Journal of Medicine. 1984 May 17;310(20):1332-1333. https://doi.org/10.1056/NEJM198405173102020
Allen, Jonathan C. ; Neville, Margaret C. ; Seacat, Joy M. ; Casey, Clare E. ; Neifert, Marianne R. ; Gahl, William A. ; Rizzo, William B. / Amino Acids in Milk in Cystinuria. In: New England Journal of Medicine. 1984 ; Vol. 310, No. 20. pp. 1332-1333.
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