Amelioration of Diabetes-like Retinal Changes in Galactose-Fed Dogs

Peter F Kador, Y. Takahashi, S. Sato, M. Wyman

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Diabetic retinopathy, the leading cause of blindness among young adults in the developed world, is characterized by vascular changes of the retinal capillary bed. Beagles fed a diet containing 30% galactose develop retinal vascular lesions that are similar to those observed in diabetics. These progress from initial retinal changes which include aldose-reductase-linked formation of pericyte ghosts and the subsequent development of acellular capillaries, microaneurysms, and intraretinal hemorrhages to the appearance of occluded vessels, areas of nonperfusion, and intraretinal microvascular abnormalities (IRMA) and in the final stages, the formation of fibrovascular membranes on both the retinal surface and the posterior hyaloid membrane. In prevention studies utilizing 0.5, 5.0, 10, and 16 mg/kg/day of the aldose reductase inhibitor M79175 (2-methyl-6-fluoro-spiro-chroman-4-5′-imidazolidine-2′,4′-dione), pericyte ghost formation, and the subsequent appearance of microaneurysms, intraretinal hemorrhages, acellular capillaries associated with background retinopathy were arrested in a dose-dependent manner. Similar dose-dependent changes in the appearance of cataracts were also observed. The dog represents the first animal model to demonstrate all of the clinical and histological retinal vessel changes observed in human diabetics.

Original languageEnglish (US)
Pages (from-to)717-721
Number of pages5
JournalPreventive Medicine
Volume23
Issue number5
DOIs
StatePublished - Jan 1 1994

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Galactose
Aldehyde Reductase
Retinal Vessels
Pericytes
Dogs
Chromans
Hemorrhage
Membranes
Diabetic Retinopathy
Blindness
Cataract
Blood Vessels
Young Adult
Animal Models
Diet
Microaneurysm

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Amelioration of Diabetes-like Retinal Changes in Galactose-Fed Dogs. / Kador, Peter F; Takahashi, Y.; Sato, S.; Wyman, M.

In: Preventive Medicine, Vol. 23, No. 5, 01.01.1994, p. 717-721.

Research output: Contribution to journalArticle

Kador, Peter F ; Takahashi, Y. ; Sato, S. ; Wyman, M. / Amelioration of Diabetes-like Retinal Changes in Galactose-Fed Dogs. In: Preventive Medicine. 1994 ; Vol. 23, No. 5. pp. 717-721.
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