Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani

Sutapa Ray, Hemanta K. Majumder, Ajit K. Chakravarty, Sibabrata Mukhopadhyay, Roberto R. Gil, Geoffrey A. Cordell

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
JournalJournal of Natural Products
Volume59
Issue number1
DOIs
StatePublished - Jan 1 1996

Fingerprint

Iridoid Glycosides
Topoisomerase I Inhibitors
DNA topoisomerase
Leishmania donovani
Type I DNA Topoisomerase
glycosides
Swertia
Swertia chirayita
Leishmania
Fractionation
catalytic activity
Catalyst activity
fractionation
extracts
Enzymes
enzymes
amarogentin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani. / Ray, Sutapa; Majumder, Hemanta K.; Chakravarty, Ajit K.; Mukhopadhyay, Sibabrata; Gil, Roberto R.; Cordell, Geoffrey A.

In: Journal of Natural Products, Vol. 59, No. 1, 01.01.1996, p. 27-29.

Research output: Contribution to journalArticle

Ray, Sutapa ; Majumder, Hemanta K. ; Chakravarty, Ajit K. ; Mukhopadhyay, Sibabrata ; Gil, Roberto R. ; Cordell, Geoffrey A. / Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani. In: Journal of Natural Products. 1996 ; Vol. 59, No. 1. pp. 27-29.
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