Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani

Sutapa Ray, Hemanta K. Majumder, Ajit K. Chakravarty, Sibabrata Mukhopadhyay, Roberto R. Gil, Geoffrey A. Cordell

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Abstract

A MeOH extract of Swertia chirata found to inhibit the catalytic activity of topoisomerase I of Leishmania donovani was subjected to fractionation to yield three secoiridoid glycosides: amarogentin (1), amaroswerin (2), and sweroside (3). Amarogentin is a potent inhibitor of type I DNA topoisomerase from Leishmania and exerts its effect by interaction with the enzyme, preventing binary complex formation.

Original languageEnglish (US)
Pages (from-to)27-29
Number of pages3
JournalJournal of Natural Products
Volume59
Issue number1
DOIs
Publication statusPublished - Jan 1 1996

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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