Altered neural function in pediatric bipolar disorder during reversal learning

Daniel P. Dickstein, Elizabeth C. Finger, Martha Skup, Daniel S. Pine, Robert James Blair, Ellen Leibenluft

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Objective: Data documenting the functional impairment associated with the diagnosis of bipolar disorder (BD) in children and adolescents highlight the need for greater understanding of its pathophysiology. Toward that end, we demonstrated previously that BD youth have behavioral deficits on reversal learning tasks. On such tasks, participants must first acquire a stimulus/response relationship through trial-and-error learning, and then discern when the stimulus/reward relationship reverses. Here, we use event-related functional magnetic resonance imaging (fMRI) to elucidate neural correlates of reversal learning deficits in euthymic BD youth compared to typically developing controls.Method: We compared euthymic pediatric BD participants (n = 16) versus age-, sex-, and IQ-matched controls (n = 16). Our main outcome measure was blood oxygen level-dependent (BOLD) signal measured with fMRI during an event-related probabilistic reversal task.Results: Pediatric BD participants had significantly greater neural activity than controls in fronto-parietal regions during the reversal phase, particularly in response to punished reversal errors (p < 0.05 corrected for multiple comparisons).Conclusions: Our current study suggests that during reversal learning, BD youths inefficiently recruit regions associated with processing response conflict and implementing alternative responses, including subdivisions of the frontal cortex and the parietal cortex. Such deficits are present in euthymic BD youth. Further work is necessary to evaluate the specificity of such alterations.

Original languageEnglish (US)
Pages (from-to)707-719
Number of pages13
JournalBipolar Disorders
Volume12
Issue number7
DOIs
StatePublished - Nov 1 2010

Fingerprint

Reversal Learning
Bipolar Disorder
Pediatrics
Parietal Lobe
Magnetic Resonance Imaging
Learning Disorders
Frontal Lobe
Reward
Outcome Assessment (Health Care)
Learning
Oxygen

Keywords

  • Adolescent
  • Bipolar disorder
  • Child
  • Magnetic resonance imaging
  • Reversal learning

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Altered neural function in pediatric bipolar disorder during reversal learning. / Dickstein, Daniel P.; Finger, Elizabeth C.; Skup, Martha; Pine, Daniel S.; Blair, Robert James; Leibenluft, Ellen.

In: Bipolar Disorders, Vol. 12, No. 7, 01.11.2010, p. 707-719.

Research output: Contribution to journalArticle

Dickstein, Daniel P. ; Finger, Elizabeth C. ; Skup, Martha ; Pine, Daniel S. ; Blair, Robert James ; Leibenluft, Ellen. / Altered neural function in pediatric bipolar disorder during reversal learning. In: Bipolar Disorders. 2010 ; Vol. 12, No. 7. pp. 707-719.
@article{27ff0b6070a84f46abd45e6eec121591,
title = "Altered neural function in pediatric bipolar disorder during reversal learning",
abstract = "Objective: Data documenting the functional impairment associated with the diagnosis of bipolar disorder (BD) in children and adolescents highlight the need for greater understanding of its pathophysiology. Toward that end, we demonstrated previously that BD youth have behavioral deficits on reversal learning tasks. On such tasks, participants must first acquire a stimulus/response relationship through trial-and-error learning, and then discern when the stimulus/reward relationship reverses. Here, we use event-related functional magnetic resonance imaging (fMRI) to elucidate neural correlates of reversal learning deficits in euthymic BD youth compared to typically developing controls.Method: We compared euthymic pediatric BD participants (n = 16) versus age-, sex-, and IQ-matched controls (n = 16). Our main outcome measure was blood oxygen level-dependent (BOLD) signal measured with fMRI during an event-related probabilistic reversal task.Results: Pediatric BD participants had significantly greater neural activity than controls in fronto-parietal regions during the reversal phase, particularly in response to punished reversal errors (p < 0.05 corrected for multiple comparisons).Conclusions: Our current study suggests that during reversal learning, BD youths inefficiently recruit regions associated with processing response conflict and implementing alternative responses, including subdivisions of the frontal cortex and the parietal cortex. Such deficits are present in euthymic BD youth. Further work is necessary to evaluate the specificity of such alterations.",
keywords = "Adolescent, Bipolar disorder, Child, Magnetic resonance imaging, Reversal learning",
author = "Dickstein, {Daniel P.} and Finger, {Elizabeth C.} and Martha Skup and Pine, {Daniel S.} and Blair, {Robert James} and Ellen Leibenluft",
year = "2010",
month = "11",
day = "1",
doi = "10.1111/j.1399-5618.2010.00863.x",
language = "English (US)",
volume = "12",
pages = "707--719",
journal = "Bipolar Disorders",
issn = "1398-5647",
publisher = "Blackwell Munksgaard",
number = "7",

}

TY - JOUR

T1 - Altered neural function in pediatric bipolar disorder during reversal learning

AU - Dickstein, Daniel P.

AU - Finger, Elizabeth C.

AU - Skup, Martha

AU - Pine, Daniel S.

AU - Blair, Robert James

AU - Leibenluft, Ellen

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Objective: Data documenting the functional impairment associated with the diagnosis of bipolar disorder (BD) in children and adolescents highlight the need for greater understanding of its pathophysiology. Toward that end, we demonstrated previously that BD youth have behavioral deficits on reversal learning tasks. On such tasks, participants must first acquire a stimulus/response relationship through trial-and-error learning, and then discern when the stimulus/reward relationship reverses. Here, we use event-related functional magnetic resonance imaging (fMRI) to elucidate neural correlates of reversal learning deficits in euthymic BD youth compared to typically developing controls.Method: We compared euthymic pediatric BD participants (n = 16) versus age-, sex-, and IQ-matched controls (n = 16). Our main outcome measure was blood oxygen level-dependent (BOLD) signal measured with fMRI during an event-related probabilistic reversal task.Results: Pediatric BD participants had significantly greater neural activity than controls in fronto-parietal regions during the reversal phase, particularly in response to punished reversal errors (p < 0.05 corrected for multiple comparisons).Conclusions: Our current study suggests that during reversal learning, BD youths inefficiently recruit regions associated with processing response conflict and implementing alternative responses, including subdivisions of the frontal cortex and the parietal cortex. Such deficits are present in euthymic BD youth. Further work is necessary to evaluate the specificity of such alterations.

AB - Objective: Data documenting the functional impairment associated with the diagnosis of bipolar disorder (BD) in children and adolescents highlight the need for greater understanding of its pathophysiology. Toward that end, we demonstrated previously that BD youth have behavioral deficits on reversal learning tasks. On such tasks, participants must first acquire a stimulus/response relationship through trial-and-error learning, and then discern when the stimulus/reward relationship reverses. Here, we use event-related functional magnetic resonance imaging (fMRI) to elucidate neural correlates of reversal learning deficits in euthymic BD youth compared to typically developing controls.Method: We compared euthymic pediatric BD participants (n = 16) versus age-, sex-, and IQ-matched controls (n = 16). Our main outcome measure was blood oxygen level-dependent (BOLD) signal measured with fMRI during an event-related probabilistic reversal task.Results: Pediatric BD participants had significantly greater neural activity than controls in fronto-parietal regions during the reversal phase, particularly in response to punished reversal errors (p < 0.05 corrected for multiple comparisons).Conclusions: Our current study suggests that during reversal learning, BD youths inefficiently recruit regions associated with processing response conflict and implementing alternative responses, including subdivisions of the frontal cortex and the parietal cortex. Such deficits are present in euthymic BD youth. Further work is necessary to evaluate the specificity of such alterations.

KW - Adolescent

KW - Bipolar disorder

KW - Child

KW - Magnetic resonance imaging

KW - Reversal learning

UR - http://www.scopus.com/inward/record.url?scp=78049516789&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049516789&partnerID=8YFLogxK

U2 - 10.1111/j.1399-5618.2010.00863.x

DO - 10.1111/j.1399-5618.2010.00863.x

M3 - Article

VL - 12

SP - 707

EP - 719

JO - Bipolar Disorders

JF - Bipolar Disorders

SN - 1398-5647

IS - 7

ER -