Altered Mucins (MUC) trafficking in Benign and malignant conditions

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Mucins are high molecular weight O-glycoproteins that are predominantly expressed at the apical surface of epithelial cells and have wide range of functions. The functional diversity is attributed to their structure that comprises of a peptide chain with unique domains and multiple carbohydrate moieties added during posttranslational modifications. Tumor cells aberrantly overexpress mucins, and thereby promote proliferation, differentiation, motility, invasion and metastasis. Along with their aberrant expression, accumulating evidence suggest the critical role of altered subcellular localization of mucins under pathological conditions due to altered endocytic processes. The mislocalization of mucins and their interactions result in change in the density and activity of important cell membrane proteins (like, receptor tyrosine kinases) to facilitate various signaling, which help cancer cells to proliferate, survive and progress to more aggressive phenotype. In this review article, we summarize studies on mucins trafficking and provide a perspective on its importance to pathological conditions and to answer critical questions including its use for therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)7272-7284
Number of pages13
JournalOncotarget
Volume5
Issue number17
DOIs
StatePublished - Jan 1 2014

Fingerprint

Mucins
Receptor Protein-Tyrosine Kinases
Therapeutic Uses
Post Translational Protein Processing
Neoplasms
Glycoproteins
Membrane Proteins
Molecular Weight
Epithelial Cells
Carbohydrates
Neoplasm Metastasis
Phenotype
Peptides

Keywords

  • Cancer
  • Endocytosis
  • Mucins
  • Plasma membrane
  • Trafficking

ASJC Scopus subject areas

  • Oncology

Cite this

Altered Mucins (MUC) trafficking in Benign and malignant conditions. / Joshi, Suhasini; Kumar, Sushil; Choudhury, Amit; Palanimuthu Ponnusamy, Moorthy; Batra, Surinder Kumar.

In: Oncotarget, Vol. 5, No. 17, 01.01.2014, p. 7272-7284.

Research output: Contribution to journalArticle

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