Altered mechanical behavior and properties of the human anterior lens capsule after cataract surgery

Ryan M Pedrigi, J. Dziezyc, J. D. Humphrey

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Several studies have quantified the mechanics of the normal lens capsule, motivated in large part by the need to understand better the mechanism of accommodation. In addition to this principal physiologic function, the lens capsule also plays a significant clinical role by housing the prosthetic lens implanted during cataract surgery. This procedure alters dramatically the mechanical environment of the capsule, which may modulate the errant behavior of lens epithelial cells that leads to capsular contraction and deposition of non-native matrix proteins. Although much is known about histological alterations within the post-surgical capsule, little is known about the altered mechanics. We performed uniaxial mechanical tests on normal and post-surgical human anterior lens capsules and found, for the first time, that cataract surgery leads to a significant stiffening of the capsule nearest the capsulorhexis edge. These data promise to be important for developing predictive tools capable of elucidating interactions between the post-surgical capsule and implant.

Original languageEnglish (US)
Pages (from-to)575-580
Number of pages6
JournalExperimental Eye Research
Volume89
Issue number4
DOIs
StatePublished - Oct 1 2009

Fingerprint

Anterior Capsule of the Lens
Cataract
Capsules
Lenses
Mechanics
Capsulorhexis
Epithelial Cells

Keywords

  • anisotropy
  • biomechanics
  • mechanical properties
  • stiffness
  • stress

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Altered mechanical behavior and properties of the human anterior lens capsule after cataract surgery. / Pedrigi, Ryan M; Dziezyc, J.; Humphrey, J. D.

In: Experimental Eye Research, Vol. 89, No. 4, 01.10.2009, p. 575-580.

Research output: Contribution to journalArticle

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