Altered Control of Ventilation in Streptozotocin-Induced Diabetic Rats

Michael S. Hein, Evelyn H. Schlenker, Kaushik P. Patel

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24 Citations (Scopus)

Abstract

The purposes of this study were (i) to determine if ventilatory control is altered in streptozotocin (STZ)-induced diabetic rats and (ii) to determine whether insulin treatment of diabetic rats could prevent ventilatory abnormalities. Male Sprague-Dawley rats were randomly assigned to three groups: control (n = 10), diabetic (n = 9), and diabetic treated with insulin (n = 9). The diabetic group exhibited a progressive reduction of tidal volume, minute ventilation, and CO2 production compared with the control and diabetic treated with Insulin groups over the 4 week period. Furthermore, the ventilatory responses to the hypercapnic (3%, 6%, 9% CO2) and hypoxic (10% O2) gas challenges were significantly less in the diabetic rats than those of the control and diabetic and Insulin treated groups by the third and fourth week. Ventilation and ventilatory responses to hypercapnia and hypoxia were similar in the control group and the diabetic treated with insulin group at the end of the study. In conclusion, uncontrolled diabetes induced in rats by STZ treatment resulted in altered control of ventilation that could be prevented by insulin therapy.

Original languageEnglish (US)
Pages (from-to)213-219
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Volume207
Issue number2
DOIs
StatePublished - Nov 1994

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Streptozocin
Ventilation
Rats
Insulin
Control Groups
Hypercapnia
Tidal Volume
Medical problems
Sprague Dawley Rats
Gases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Altered Control of Ventilation in Streptozotocin-Induced Diabetic Rats. / Hein, Michael S.; Schlenker, Evelyn H.; Patel, Kaushik P.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 207, No. 2, 11.1994, p. 213-219.

Research output: Contribution to journalArticle

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