Alterations in the rat kidney associated with sodium saccharin feeding: A scanning electron microscopic study

Theodore D. Miller, Samuel Monroe Cohen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Sodium saccharin has previously been demonstrated to induce hyperplasia of the urothelium of the rat kidney pelvis. It was fed as 5% of the diet to male F344 rats for 18 weeks. In the present experiment, scanning electron microscopy (SEM) was utilized to detect early morphologic changes. Pleomorphic microvilli (PMV) were observed in all four sodium saccharin-fed rats, located on cells at the junction of the papilla and pelvis. PMV also occurred at the papilla-pelvic junction in three of the ten control rats, but the affected area was smaller and the PMV exhibited less severe atypia.

Original languageEnglish (US)
Pages (from-to)177-181
Number of pages5
JournalToxicology Letters
Volume20
Issue number2
DOIs
StatePublished - Feb 1984

Fingerprint

Saccharin
Microvilli
Rats
Electrons
Scanning
Kidney
Rat control
Urothelium
Kidney Pelvis
Intercellular Junctions
Inbred F344 Rats
Nutrition
Pelvis
Electron Scanning Microscopy
Hyperplasia
Diet
Scanning electron microscopy
Experiments

Keywords

  • Pelvis
  • hyperplasia
  • microvilli
  • saccharin
  • scanning electron microscopy

ASJC Scopus subject areas

  • Toxicology

Cite this

Alterations in the rat kidney associated with sodium saccharin feeding : A scanning electron microscopic study. / Miller, Theodore D.; Cohen, Samuel Monroe.

In: Toxicology Letters, Vol. 20, No. 2, 02.1984, p. 177-181.

Research output: Contribution to journalArticle

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