Alterations in pulse pressure affect artery function

Danika M. Hayman, Yangming Xiao, Qingping Yao, Zonglai Jiang, Merry L Lindsey, Hai Chao Han

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Pulse pressure changes in response to cardiovascular diseases and interventions, but its effect on vascular wall structure and function is poorly understood. We examined the effect of increased or decreased pulse pressure on artery function, cellular function, and extracellular matrix remodeling. Porcine carotid arteries were cultured under non-pulsatile (100 mmHg), pulsatile (70-130 mmHg), or hyper-pulsatile pressure (50-150 mmHg) for 1-3 days. Vasomotor response, wall permeability, cell proliferation, apoptosis, extracellular matrix remodeling, and proteins involved in atherogenesis were examined. Our results showed that hyper-pulsatile pressure decreased the artery response to sodium nitroprusside, basal tone, and wall permeability after 3 days. Non-pulsatile pressure increased cell proliferation. Neither hyper-pulsatile nor non-pulsatile pressure caused a change in the extracellular matrix or in the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, caveolin-1, or a-actin. Hyper-pulsatile pressure increased monocyte chemotactic protein-1 gene expression. Taken together, these changes indicate that pulse pressure has a limited effect on the artery immediately after its application. Specifically an increase in pulse pressure alters the artery tone and wall permeability while a decrease in pulse pressure alters cell proliferation. Overall these results provide insight into how the artery initially responds to changes in pulse pressure.

Original languageEnglish (US)
Pages (from-to)474-487
Number of pages14
JournalCellular and Molecular Bioengineering
Volume5
Issue number4
DOIs
StatePublished - Dec 1 2012

Fingerprint

Arteries
Blood Pressure
Pressure
Permeability
Cell Proliferation
Cell proliferation
Extracellular Matrix
Remodeling
Caveolin 1
Chemokine CCL2
Extracellular Matrix Proteins
Matrix Metalloproteinase 2
Nitroprusside
Matrix Metalloproteinases
Carotid Arteries
Blood Vessels
Actins
Atherosclerosis
Cardiovascular Diseases
Swine

Keywords

  • Cell proliferation
  • Ex vivo organ culture
  • Matrix metalloproteinase
  • Monocyte chemotactic protein-1
  • Permeability
  • Porcine artery
  • Pulsatile pressure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Modeling and Simulation

Cite this

Alterations in pulse pressure affect artery function. / Hayman, Danika M.; Xiao, Yangming; Yao, Qingping; Jiang, Zonglai; Lindsey, Merry L; Han, Hai Chao.

In: Cellular and Molecular Bioengineering, Vol. 5, No. 4, 01.12.2012, p. 474-487.

Research output: Contribution to journalArticle

Hayman, Danika M. ; Xiao, Yangming ; Yao, Qingping ; Jiang, Zonglai ; Lindsey, Merry L ; Han, Hai Chao. / Alterations in pulse pressure affect artery function. In: Cellular and Molecular Bioengineering. 2012 ; Vol. 5, No. 4. pp. 474-487.
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