Alterations in cortical activation among individuals with chronic ankle instability during single-limb postural control

Adam B Rosen, Jennifer M. Yentes, Melanie L. McGrath, Arthur C Maerlender, Sara A Myers, Mukul Mukherjee

Research output: Contribution to journalArticle

Abstract

Context: Chronic ankle instability (CAI) is characterized by repetitive ankle sprains and perceived instability. Whereas the underlying cause of CAI is disputed, alterations in cortical motor functioning may contribute to the perceived dysfunction. Objective: To assess differences in cortical activity during single-limb stance among control, coper, and CAI groups. Design: Cross-sectional study. Setting: Biomechanics laboratory. Patients or Other Participants: A total of 31 individuals (10 men, 21 women; age ¼ 22.3 6 2.4 years, height ¼ 169.6 6 9.7 cm, mass ¼ 70.6 6 11.6 kg), who were classified into control (n ¼ 13), coper (n ¼ 7), and CAI (n ¼ 11) groups participated in this study. Intervention(s): Participants performed single-limb stance on a force platform for 60 seconds while wearing a 24-channel functional near-infrared spectroscopy system. Oxyhemoglobin (HbO2) changes in the supplementary motor area (SMA), precentral gyrus, postcentral gyrus, and superior parietal lobe were measured. Main Outcome Measure(s): Differences in averages and standard deviations of HbO2 were assessed across groups. In the CAI group, correlations were analyzed between measures of cortical activation and Cumberland Ankle Instability Tool (CAIT) scores. Results: No differences in average HbO2 were present for any cortical areas. We observed differences in the standard deviation for the SMA across groups; specifically, the CAI group demonstrated greater variability than the control (r ¼ 0.395, P ¼ .02; 95% confidence interval ¼ 0.34, 0.67) and coper (r ¼ 0.38, P ¼ .04; 95% confidence interval ¼ 0.05, 0.69) groups. We demonstrated a strong correlation that was significant in the CAI group between the CAIT score and the average HbO2 of the precentral gyrus (q ¼ 0.64, P ¼ .02) and a strong correlation that was not significant between the CAIT score and the average HbO2 of the SMA (q ¼ 0.52, P ¼ .06). Conclusions: The CAI group displayed large differences in SMA cortical-activation variability. Greater variations in cortical activation may be necessary for similar static postural-control outcomes among individuals with CAI. Consequently, variations in cortical activation for these areas provide evidence for an altered neural mechanism of postural control among populations with CAI.

Original languageEnglish (US)
Pages (from-to)718-726
Number of pages9
JournalJournal of Athletic Training
Volume54
Issue number6
DOIs
StatePublished - Jan 1 2019

Fingerprint

Ankle
Extremities
Motor Cortex
Frontal Lobe
Confidence Intervals
Ankle Injuries
Oxyhemoglobins
Parietal Lobe
Somatosensory Cortex
Near-Infrared Spectroscopy
Biomechanical Phenomena
Cross-Sectional Studies
Outcome Assessment (Health Care)

Keywords

  • Balance
  • Central nervous system
  • Cortical-activation variability
  • Functional near-infrared spectroscopy
  • Stability

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Alterations in cortical activation among individuals with chronic ankle instability during single-limb postural control. / Rosen, Adam B; Yentes, Jennifer M.; McGrath, Melanie L.; Maerlender, Arthur C; Myers, Sara A; Mukherjee, Mukul.

In: Journal of Athletic Training, Vol. 54, No. 6, 01.01.2019, p. 718-726.

Research output: Contribution to journalArticle

@article{bd2feb70dc564dbab9942831c5944d12,
title = "Alterations in cortical activation among individuals with chronic ankle instability during single-limb postural control",
abstract = "Context: Chronic ankle instability (CAI) is characterized by repetitive ankle sprains and perceived instability. Whereas the underlying cause of CAI is disputed, alterations in cortical motor functioning may contribute to the perceived dysfunction. Objective: To assess differences in cortical activity during single-limb stance among control, coper, and CAI groups. Design: Cross-sectional study. Setting: Biomechanics laboratory. Patients or Other Participants: A total of 31 individuals (10 men, 21 women; age ¼ 22.3 6 2.4 years, height ¼ 169.6 6 9.7 cm, mass ¼ 70.6 6 11.6 kg), who were classified into control (n ¼ 13), coper (n ¼ 7), and CAI (n ¼ 11) groups participated in this study. Intervention(s): Participants performed single-limb stance on a force platform for 60 seconds while wearing a 24-channel functional near-infrared spectroscopy system. Oxyhemoglobin (HbO2) changes in the supplementary motor area (SMA), precentral gyrus, postcentral gyrus, and superior parietal lobe were measured. Main Outcome Measure(s): Differences in averages and standard deviations of HbO2 were assessed across groups. In the CAI group, correlations were analyzed between measures of cortical activation and Cumberland Ankle Instability Tool (CAIT) scores. Results: No differences in average HbO2 were present for any cortical areas. We observed differences in the standard deviation for the SMA across groups; specifically, the CAI group demonstrated greater variability than the control (r ¼ 0.395, P ¼ .02; 95{\%} confidence interval ¼ 0.34, 0.67) and coper (r ¼ 0.38, P ¼ .04; 95{\%} confidence interval ¼ 0.05, 0.69) groups. We demonstrated a strong correlation that was significant in the CAI group between the CAIT score and the average HbO2 of the precentral gyrus (q ¼ 0.64, P ¼ .02) and a strong correlation that was not significant between the CAIT score and the average HbO2 of the SMA (q ¼ 0.52, P ¼ .06). Conclusions: The CAI group displayed large differences in SMA cortical-activation variability. Greater variations in cortical activation may be necessary for similar static postural-control outcomes among individuals with CAI. Consequently, variations in cortical activation for these areas provide evidence for an altered neural mechanism of postural control among populations with CAI.",
keywords = "Balance, Central nervous system, Cortical-activation variability, Functional near-infrared spectroscopy, Stability",
author = "Rosen, {Adam B} and Yentes, {Jennifer M.} and McGrath, {Melanie L.} and Maerlender, {Arthur C} and Myers, {Sara A} and Mukul Mukherjee",
year = "2019",
month = "1",
day = "1",
doi = "10.4085/1062-6050-448-17",
language = "English (US)",
volume = "54",
pages = "718--726",
journal = "Journal of Athletic Training",
issn = "1062-6050",
publisher = "National Athletic Trainers' Association Inc.",
number = "6",

}

TY - JOUR

T1 - Alterations in cortical activation among individuals with chronic ankle instability during single-limb postural control

AU - Rosen, Adam B

AU - Yentes, Jennifer M.

AU - McGrath, Melanie L.

AU - Maerlender, Arthur C

AU - Myers, Sara A

AU - Mukherjee, Mukul

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Context: Chronic ankle instability (CAI) is characterized by repetitive ankle sprains and perceived instability. Whereas the underlying cause of CAI is disputed, alterations in cortical motor functioning may contribute to the perceived dysfunction. Objective: To assess differences in cortical activity during single-limb stance among control, coper, and CAI groups. Design: Cross-sectional study. Setting: Biomechanics laboratory. Patients or Other Participants: A total of 31 individuals (10 men, 21 women; age ¼ 22.3 6 2.4 years, height ¼ 169.6 6 9.7 cm, mass ¼ 70.6 6 11.6 kg), who were classified into control (n ¼ 13), coper (n ¼ 7), and CAI (n ¼ 11) groups participated in this study. Intervention(s): Participants performed single-limb stance on a force platform for 60 seconds while wearing a 24-channel functional near-infrared spectroscopy system. Oxyhemoglobin (HbO2) changes in the supplementary motor area (SMA), precentral gyrus, postcentral gyrus, and superior parietal lobe were measured. Main Outcome Measure(s): Differences in averages and standard deviations of HbO2 were assessed across groups. In the CAI group, correlations were analyzed between measures of cortical activation and Cumberland Ankle Instability Tool (CAIT) scores. Results: No differences in average HbO2 were present for any cortical areas. We observed differences in the standard deviation for the SMA across groups; specifically, the CAI group demonstrated greater variability than the control (r ¼ 0.395, P ¼ .02; 95% confidence interval ¼ 0.34, 0.67) and coper (r ¼ 0.38, P ¼ .04; 95% confidence interval ¼ 0.05, 0.69) groups. We demonstrated a strong correlation that was significant in the CAI group between the CAIT score and the average HbO2 of the precentral gyrus (q ¼ 0.64, P ¼ .02) and a strong correlation that was not significant between the CAIT score and the average HbO2 of the SMA (q ¼ 0.52, P ¼ .06). Conclusions: The CAI group displayed large differences in SMA cortical-activation variability. Greater variations in cortical activation may be necessary for similar static postural-control outcomes among individuals with CAI. Consequently, variations in cortical activation for these areas provide evidence for an altered neural mechanism of postural control among populations with CAI.

AB - Context: Chronic ankle instability (CAI) is characterized by repetitive ankle sprains and perceived instability. Whereas the underlying cause of CAI is disputed, alterations in cortical motor functioning may contribute to the perceived dysfunction. Objective: To assess differences in cortical activity during single-limb stance among control, coper, and CAI groups. Design: Cross-sectional study. Setting: Biomechanics laboratory. Patients or Other Participants: A total of 31 individuals (10 men, 21 women; age ¼ 22.3 6 2.4 years, height ¼ 169.6 6 9.7 cm, mass ¼ 70.6 6 11.6 kg), who were classified into control (n ¼ 13), coper (n ¼ 7), and CAI (n ¼ 11) groups participated in this study. Intervention(s): Participants performed single-limb stance on a force platform for 60 seconds while wearing a 24-channel functional near-infrared spectroscopy system. Oxyhemoglobin (HbO2) changes in the supplementary motor area (SMA), precentral gyrus, postcentral gyrus, and superior parietal lobe were measured. Main Outcome Measure(s): Differences in averages and standard deviations of HbO2 were assessed across groups. In the CAI group, correlations were analyzed between measures of cortical activation and Cumberland Ankle Instability Tool (CAIT) scores. Results: No differences in average HbO2 were present for any cortical areas. We observed differences in the standard deviation for the SMA across groups; specifically, the CAI group demonstrated greater variability than the control (r ¼ 0.395, P ¼ .02; 95% confidence interval ¼ 0.34, 0.67) and coper (r ¼ 0.38, P ¼ .04; 95% confidence interval ¼ 0.05, 0.69) groups. We demonstrated a strong correlation that was significant in the CAI group between the CAIT score and the average HbO2 of the precentral gyrus (q ¼ 0.64, P ¼ .02) and a strong correlation that was not significant between the CAIT score and the average HbO2 of the SMA (q ¼ 0.52, P ¼ .06). Conclusions: The CAI group displayed large differences in SMA cortical-activation variability. Greater variations in cortical activation may be necessary for similar static postural-control outcomes among individuals with CAI. Consequently, variations in cortical activation for these areas provide evidence for an altered neural mechanism of postural control among populations with CAI.

KW - Balance

KW - Central nervous system

KW - Cortical-activation variability

KW - Functional near-infrared spectroscopy

KW - Stability

UR - http://www.scopus.com/inward/record.url?scp=85068885144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068885144&partnerID=8YFLogxK

U2 - 10.4085/1062-6050-448-17

DO - 10.4085/1062-6050-448-17

M3 - Article

C2 - 31162942

AN - SCOPUS:85068885144

VL - 54

SP - 718

EP - 726

JO - Journal of Athletic Training

JF - Journal of Athletic Training

SN - 1062-6050

IS - 6

ER -