Alterations in brain hexokinase activity associated with heart failure in rats

K. P. Patel, P. L. Zhang, T. L. Krukoff

Research output: Contribution to journalArticle

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Abstract

This study examined the activity of discrete regions of the brain as assessed with histological localization and photodensitometric quantification of the metabolic enzyme hexokinase in a group of rats with coronary occlusion (HF) and in sham-operated control rats. Three weeks after surgery, the mean left ventricular end diastolic pressure and right atrial pressure were elevated, and left ventricular peak systolic pressure was decreased in the HF group compared with the sham group; these findings are also observed during heart failure. In addition, histological data indicated that there was a 37.6 ± 2.8% outer and 40.8 ± 3.1% inner infarct of the myocardium in the group of rats with HF (n = 6). Rats in the control group had no observable damage to the myocardium (n = 6). Accompanying these symptoms of heart failure were significant increases in hexokinase activity in the parvocellular (pPVN, 16.3%) and magnocellular (mPVN, 17.6%) divisions of the paraventricular nucleus of the hypothalamus, and in the locus ceruleus (LC, 17.1%). No changes in hexokinase activity were observed in the median preoptic area, supraoptic nucleus (SON), subfornical organ, or posterior hypothalamus. These results reinforce the idea that heart failure (with coronary occlusion) is associated with changes in specific areas in the brain and that metabolic alterations in the pPVN, mPVN, and LC are likely related to alterations in vasopressin production, blood volume regulation, and sympathoexcitation observed in the heart failure state.

Original languageEnglish (US)
Pages (from-to)R923-R928
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume265
Issue number4 34-4
StatePublished - Nov 15 1993

Fingerprint

Hexokinase
Heart Failure
Coronary Occlusion
Brain
Myocardium
Subfornical Organ
Posterior Hypothalamus
Blood Pressure
Supraoptic Nucleus
Preoptic Area
Atrial Pressure
Locus Coeruleus
Paraventricular Hypothalamic Nucleus
Blood Volume
Vasopressins
Hypothalamus
Control Groups
Enzymes

Keywords

  • hexokinase
  • histochemistry
  • locus ceruleus
  • paraventricular nucleus

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Alterations in brain hexokinase activity associated with heart failure in rats. / Patel, K. P.; Zhang, P. L.; Krukoff, T. L.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 265, No. 4 34-4, 15.11.1993, p. R923-R928.

Research output: Contribution to journalArticle

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