Alpha-crystallins and tumorigenesis

P. Chen, W. Ji, F. Y. Liu, H. Z. Tang, S. Fu, X. Zhang, M. Liu, L. Gong, M. Deng, W. F. Hu, X. H. Hu, X. W. Chen, Z. L. Li, X. Li, J. Liu, D. W.C. Li

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

αA-and αB-crystallins, the major lens structure proteins and members of the small heat-shock proteins (sHSPs) family, play essential roles in maintaining normal cellular structure and physiology of both ocular and some non-ocular tissues. Mutations and abnormal expression of these sHSPs are associated with various human diseases such as cataract, neural disorders, and cardiovascular diseases. In addition, recent studies have revealed that the abnormal expressions and functions of both α-crystallins are associated with several types of tumors. In this regard, αA- and αB-crystallins seem to function differentially or even oppositely during tumorigenesis, and diverse molecular mechanisms have been proposed to explain their roles in cell apoptosis, cell proliferation and tumor metastasis. In this review, we have summarized the current status regarding the expression patterns and functions of αA- and αB-crystallins implicated in tumorigenesis, and discussed the possible mechanisms underlying their functions.

Original languageEnglish (US)
Pages (from-to)1164-1173
Number of pages10
JournalCurrent Molecular Medicine
Volume12
Issue number9
DOIs
StatePublished - Oct 29 2012

Fingerprint

alpha-Crystallins
Crystallins
Carcinogenesis
Small Heat-Shock Proteins
Tumors
Ocular Physiological Phenomena
Physiology
Cell proliferation
Lenses
Cellular Structures
Cataract
Tissue
Apoptosis
Neoplasms
Cardiovascular Diseases
Cell Proliferation
Neoplasm Metastasis
Mutation
Proteins

Keywords

  • Apoptosis
  • Cancer
  • Lens
  • Metastasis
  • Pancreas
  • Tumor
  • Tumorigenesis
  • αA-/αB-crystallin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

Chen, P., Ji, W., Liu, F. Y., Tang, H. Z., Fu, S., Zhang, X., ... Li, D. W. C. (2012). Alpha-crystallins and tumorigenesis. Current Molecular Medicine, 12(9), 1164-1173. https://doi.org/10.2174/156652412803306747

Alpha-crystallins and tumorigenesis. / Chen, P.; Ji, W.; Liu, F. Y.; Tang, H. Z.; Fu, S.; Zhang, X.; Liu, M.; Gong, L.; Deng, M.; Hu, W. F.; Hu, X. H.; Chen, X. W.; Li, Z. L.; Li, X.; Liu, J.; Li, D. W.C.

In: Current Molecular Medicine, Vol. 12, No. 9, 29.10.2012, p. 1164-1173.

Research output: Contribution to journalReview article

Chen, P, Ji, W, Liu, FY, Tang, HZ, Fu, S, Zhang, X, Liu, M, Gong, L, Deng, M, Hu, WF, Hu, XH, Chen, XW, Li, ZL, Li, X, Liu, J & Li, DWC 2012, 'Alpha-crystallins and tumorigenesis', Current Molecular Medicine, vol. 12, no. 9, pp. 1164-1173. https://doi.org/10.2174/156652412803306747
Chen P, Ji W, Liu FY, Tang HZ, Fu S, Zhang X et al. Alpha-crystallins and tumorigenesis. Current Molecular Medicine. 2012 Oct 29;12(9):1164-1173. https://doi.org/10.2174/156652412803306747
Chen, P. ; Ji, W. ; Liu, F. Y. ; Tang, H. Z. ; Fu, S. ; Zhang, X. ; Liu, M. ; Gong, L. ; Deng, M. ; Hu, W. F. ; Hu, X. H. ; Chen, X. W. ; Li, Z. L. ; Li, X. ; Liu, J. ; Li, D. W.C. / Alpha-crystallins and tumorigenesis. In: Current Molecular Medicine. 2012 ; Vol. 12, No. 9. pp. 1164-1173.
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