Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery

Bruce J. Melancon, Corey R. Hopkins, Michael R. Wood, Kyle A. Emmitte, Colleen M. Niswender, Arthur Christopoulos, P. Jeffrey Conn, Craig W. Lindsley

Research output: Contribution to journalReview article

162 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)1445-1464
Number of pages20
JournalJournal of Medicinal Chemistry
Volume55
Issue number4
DOIs
StatePublished - Feb 23 2012

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Allosteric Regulation
Central Nervous System Agents
Metabotropic Glutamate Receptors
Muscarinic Receptors
Drug Discovery
Structure-Activity Relationship
G-Protein-Coupled Receptors
Ligands

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Allosteric modulation of seven transmembrane spanning receptors : Theory, practice, and opportunities for central nervous system drug discovery. / Melancon, Bruce J.; Hopkins, Corey R.; Wood, Michael R.; Emmitte, Kyle A.; Niswender, Colleen M.; Christopoulos, Arthur; Conn, P. Jeffrey; Lindsley, Craig W.

In: Journal of Medicinal Chemistry, Vol. 55, No. 4, 23.02.2012, p. 1445-1464.

Research output: Contribution to journalReview article

Melancon, Bruce J. ; Hopkins, Corey R. ; Wood, Michael R. ; Emmitte, Kyle A. ; Niswender, Colleen M. ; Christopoulos, Arthur ; Conn, P. Jeffrey ; Lindsley, Craig W. / Allosteric modulation of seven transmembrane spanning receptors : Theory, practice, and opportunities for central nervous system drug discovery. In: Journal of Medicinal Chemistry. 2012 ; Vol. 55, No. 4. pp. 1445-1464.
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