Allosteric modulation of seven transmembrane spanning receptors

Theory, practice, and opportunities for central nervous system drug discovery

Bruce J. Melancon, Corey R Hopkins, Michael R. Wood, Kyle A. Emmitte, Colleen M. Niswender, Arthur Christopoulos, P. Jeffrey Conn, Craig W. Lindsley

Research output: Contribution to journalReview article

162 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)1445-1464
Number of pages20
JournalJournal of Medicinal Chemistry
Volume55
Issue number4
DOIs
StatePublished - Feb 23 2012

Fingerprint

Allosteric Regulation
Central Nervous System Agents
Metabotropic Glutamate Receptors
Muscarinic Receptors
Drug Discovery
Structure-Activity Relationship
G-Protein-Coupled Receptors
Ligands

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Allosteric modulation of seven transmembrane spanning receptors : Theory, practice, and opportunities for central nervous system drug discovery. / Melancon, Bruce J.; Hopkins, Corey R; Wood, Michael R.; Emmitte, Kyle A.; Niswender, Colleen M.; Christopoulos, Arthur; Conn, P. Jeffrey; Lindsley, Craig W.

In: Journal of Medicinal Chemistry, Vol. 55, No. 4, 23.02.2012, p. 1445-1464.

Research output: Contribution to journalReview article

Melancon, Bruce J. ; Hopkins, Corey R ; Wood, Michael R. ; Emmitte, Kyle A. ; Niswender, Colleen M. ; Christopoulos, Arthur ; Conn, P. Jeffrey ; Lindsley, Craig W. / Allosteric modulation of seven transmembrane spanning receptors : Theory, practice, and opportunities for central nervous system drug discovery. In: Journal of Medicinal Chemistry. 2012 ; Vol. 55, No. 4. pp. 1445-1464.
@article{48153e30e9394c678ac47c2ee655b3d1,
title = "Allosteric modulation of seven transmembrane spanning receptors: Theory, practice, and opportunities for central nervous system drug discovery",
author = "Melancon, {Bruce J.} and Hopkins, {Corey R} and Wood, {Michael R.} and Emmitte, {Kyle A.} and Niswender, {Colleen M.} and Arthur Christopoulos and Conn, {P. Jeffrey} and Lindsley, {Craig W.}",
year = "2012",
month = "2",
day = "23",
doi = "10.1021/jm201139r",
language = "English (US)",
volume = "55",
pages = "1445--1464",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
publisher = "American Chemical Society",
number = "4",

}

TY - JOUR

T1 - Allosteric modulation of seven transmembrane spanning receptors

T2 - Theory, practice, and opportunities for central nervous system drug discovery

AU - Melancon, Bruce J.

AU - Hopkins, Corey R

AU - Wood, Michael R.

AU - Emmitte, Kyle A.

AU - Niswender, Colleen M.

AU - Christopoulos, Arthur

AU - Conn, P. Jeffrey

AU - Lindsley, Craig W.

PY - 2012/2/23

Y1 - 2012/2/23

UR - http://www.scopus.com/inward/record.url?scp=84857375139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857375139&partnerID=8YFLogxK

U2 - 10.1021/jm201139r

DO - 10.1021/jm201139r

M3 - Review article

VL - 55

SP - 1445

EP - 1464

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 4

ER -