Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep

U. DeSilva, X. Guo, D. M. Kupfer, S. C. Fernando, A. T.V. Pillai, F. Z. Najar, S. So, G. Q. Fitch, B. A. Roe

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

1,144 sheep belonging to 21 breeds and known crosses were sequence analyzed for polymorphisms in the ovine PRNP gene. Genotype and allele frequencies of polymorphisms in PRNP known to confer resistance to scrapie, a fatal neurodegenerative disease of sheep, are reported. Known polymorphisms at codons 136 (A/V), 154 (H/R) and 171 (Q/R/H/K) were identified. The frequency of the 171R allele known to confer resistance to type C scrapie was 53.8% and the frequency of the 136A allele known to influence the resistance to type A scrapie was 96.01%. In addition, we report the identification of five new polymorphisms at codons 143 (H/R), 167 (R/S), 180 (H/Y), 195 (T/S) and 196 (T/S). We also report the identification of a novel allele (S/R) at codon 138.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalCytogenetic and Genome Research
Volume102
Issue number1-4
DOIs
StatePublished - Dec 1 2003

Fingerprint

Scrapie
Gene Frequency
Codon
Sheep
Genes
Neurodegenerative Diseases
Alleles
Genotype
Prion Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

Cite this

DeSilva, U., Guo, X., Kupfer, D. M., Fernando, S. C., Pillai, A. T. V., Najar, F. Z., ... Roe, B. A. (2003). Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep. Cytogenetic and Genome Research, 102(1-4), 89-94. https://doi.org/10.1159/000075731

Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep. / DeSilva, U.; Guo, X.; Kupfer, D. M.; Fernando, S. C.; Pillai, A. T.V.; Najar, F. Z.; So, S.; Fitch, G. Q.; Roe, B. A.

In: Cytogenetic and Genome Research, Vol. 102, No. 1-4, 01.12.2003, p. 89-94.

Research output: Contribution to journalArticle

DeSilva, U, Guo, X, Kupfer, DM, Fernando, SC, Pillai, ATV, Najar, FZ, So, S, Fitch, GQ & Roe, BA 2003, 'Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep', Cytogenetic and Genome Research, vol. 102, no. 1-4, pp. 89-94. https://doi.org/10.1159/000075731
DeSilva, U. ; Guo, X. ; Kupfer, D. M. ; Fernando, S. C. ; Pillai, A. T.V. ; Najar, F. Z. ; So, S. ; Fitch, G. Q. ; Roe, B. A. / Allelic variants of ovine prion protein gene (PRNP) in Oklahoma sheep. In: Cytogenetic and Genome Research. 2003 ; Vol. 102, No. 1-4. pp. 89-94.
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