Aldose reductase localization in dog retinal mural cells

Yoshio Akagi, Hirofumi Terubayashi, Jane Millen, Peter F Kador, Jin H. Kinoshita

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The selective degeneration of retinal mural cells, a hallmark of early human diabetic retinopathy, has also been reported to occur in both diabetic and galactose-fed dogs. By employing antibodies raised against purified dog lens aldose reductase the presence of aldose reductase can be immunohisto-chemically demonstrated in the cytoplasm of mural cells but not endothelial cells of dog retinal vessels isolated by trypsin digestion. This immunohisto-chemical staining is similar to that observed with isolated human retinal vessels.

Original languageEnglish (US)
Pages (from-to)883-886
Number of pages4
JournalCurrent Eye Research
Volume5
Issue number11
DOIs
StatePublished - Jan 1 1986

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Aldehyde Reductase
Retinal Vessels
Dogs
Retinal Degeneration
Diabetic Retinopathy
Galactose
Trypsin
Lenses
Digestion
Cytoplasm
Endothelial Cells
Staining and Labeling
Antibodies

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Aldose reductase localization in dog retinal mural cells. / Akagi, Yoshio; Terubayashi, Hirofumi; Millen, Jane; Kador, Peter F; Kinoshita, Jin H.

In: Current Eye Research, Vol. 5, No. 11, 01.01.1986, p. 883-886.

Research output: Contribution to journalArticle

Akagi, Y, Terubayashi, H, Millen, J, Kador, PF & Kinoshita, JH 1986, 'Aldose reductase localization in dog retinal mural cells', Current Eye Research, vol. 5, no. 11, pp. 883-886. https://doi.org/10.3109/02713688609029241
Akagi, Yoshio ; Terubayashi, Hirofumi ; Millen, Jane ; Kador, Peter F ; Kinoshita, Jin H. / Aldose reductase localization in dog retinal mural cells. In: Current Eye Research. 1986 ; Vol. 5, No. 11. pp. 883-886.
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