Aldose reductase and ϱ-crystallin belong to the same protein superfamily as aldehyde reductase

Deborah Carper, Chihiro Nishimura, Toshimichi Shinohara, Bernard Dietzchold, Graeme Wistow, Cheryl Craft, Peter Kador, Jin H. Kinoshita

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129 Scopus citations

Abstract

Aldose reductase (EC 1.1.1.21) has been implicated in a variety of diabetic complications. Here we present the first primary sequence data for the rat lens enzyme, obtained by amino acid and cDNA analysis. We have found structural similarities with another NADPH-dependent oxidoreductase: human liver aldehyde reductase (EC 1.1.1.2). The identity between these two enzymes is 50%. Both enzymes share approx. 40-50% homology with ρ{variant}-crystallin, a major lens protein present only in the frog, Rana pipiens. We propose that aldose reductase, aldehyde reductase and ρ{variant}-crystallin are members of a superfamily of related proteins.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalFEBS Letters
Volume220
Issue number1
DOIs
Publication statusPublished - Aug 10 1987

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Keywords

  • Aldehyde reductase
  • Aldose reductase
  • Structural homology
  • cDNA sequence
  • ρ{variant}-Crystallin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Carper, D., Nishimura, C., Shinohara, T., Dietzchold, B., Wistow, G., Craft, C., ... Kinoshita, J. H. (1987). Aldose reductase and ϱ-crystallin belong to the same protein superfamily as aldehyde reductase. FEBS Letters, 220(1), 209-213. https://doi.org/10.1016/0014-5793(87)80905-5