Aldose reductase and ρ{variant}-crystallin belong to the same protein superfamily as aldehyde reductase

Deborah Carper, Chihiro Nishimura, Toshimichi Shinohara, Bernard Dietzchold, Graeme Wistow, Cheryl Craft, Peter Kador, Jin H. Kinoshita

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Aldose reductase (EC 1.1.1.21) has been implicated in a variety of diabetic complications. Here we present the first primary sequence data for the rat lens enzyme, obtained by amino acid and cDNA analysis. We have found structural similarities with another NADPH-dependent oxidoreductase: human liver aldehyde reductase (EC 1.1.1.2). The identity between these two enzymes is 50%. Both enzymes share approx. 40-50% homology with ρ{variant}-crystallin, a major lens protein present only in the frog, Rana pipiens. We propose that aldose reductase, aldehyde reductase and ρ{variant}-crystallin are members of a superfamily of related proteins.

Original languageEnglish (US)
Pages (from-to)209-213
Number of pages5
JournalFEBS Letters
Volume220
Issue number1
DOIs
StatePublished - Aug 10 1987

Fingerprint

Aldehyde Reductase
Crystallins
Proteins
Enzymes
Rana pipiens
Diabetes Complications
NADP
Anura
Liver
Lenses
Rats
Oxidoreductases
Complementary DNA
Amino Acids

Keywords

  • Aldehyde reductase
  • Aldose reductase
  • Structural homology
  • cDNA sequence
  • ρ{variant}-Crystallin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Carper, D., Nishimura, C., Shinohara, T., Dietzchold, B., Wistow, G., Craft, C., ... Kinoshita, J. H. (1987). Aldose reductase and ρ{variant}-crystallin belong to the same protein superfamily as aldehyde reductase. FEBS Letters, 220(1), 209-213. https://doi.org/10.1016/0014-5793(87)80905-5

Aldose reductase and ρ{variant}-crystallin belong to the same protein superfamily as aldehyde reductase. / Carper, Deborah; Nishimura, Chihiro; Shinohara, Toshimichi; Dietzchold, Bernard; Wistow, Graeme; Craft, Cheryl; Kador, Peter; Kinoshita, Jin H.

In: FEBS Letters, Vol. 220, No. 1, 10.08.1987, p. 209-213.

Research output: Contribution to journalArticle

Carper, D, Nishimura, C, Shinohara, T, Dietzchold, B, Wistow, G, Craft, C, Kador, P & Kinoshita, JH 1987, 'Aldose reductase and ρ{variant}-crystallin belong to the same protein superfamily as aldehyde reductase', FEBS Letters, vol. 220, no. 1, pp. 209-213. https://doi.org/10.1016/0014-5793(87)80905-5
Carper D, Nishimura C, Shinohara T, Dietzchold B, Wistow G, Craft C et al. Aldose reductase and ρ{variant}-crystallin belong to the same protein superfamily as aldehyde reductase. FEBS Letters. 1987 Aug 10;220(1):209-213. https://doi.org/10.1016/0014-5793(87)80905-5
Carper, Deborah ; Nishimura, Chihiro ; Shinohara, Toshimichi ; Dietzchold, Bernard ; Wistow, Graeme ; Craft, Cheryl ; Kador, Peter ; Kinoshita, Jin H. / Aldose reductase and ρ{variant}-crystallin belong to the same protein superfamily as aldehyde reductase. In: FEBS Letters. 1987 ; Vol. 220, No. 1. pp. 209-213.
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