Alcoholic liver disease: Quantitative image-guided P-31 MR spectroscopy

D. J. Meyerhoff, M. D. Boska, A. M. Thomas, M. W. Weiner

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Phosphorus-31 magnetic resonance (MR) spectroscopy was performed on the liver of patients with alcoholic hepatitis (n=10), alcoholic cirrhosis (n=9), and viral hepatitis B (n=3) and on healthy control subjects (n=21). A hydrogen-1 MR image-guided localization technique (ISIS) was used to acquire P-31 spectra selectively from a volume of interest within the liver. Spectra were analyzed to yield absolute molar concentrations of hepatic phosphomonoesters, phosphodiesters, inorganic phosphate, and adenosine triphosphate. It was found that (a) hepatic metabolite ratios in alcoholic liver disease were not significantly different from those in healthy subjects, (b) absolute hepatic metabolite concentrations were decreased by 25%-46% in alcoholic hepatitis and 13%-50% in alcoholic cirrhosis compared with those in healthy subjects, and (c) hepatic intracellular pH was 7.4 in healthy subjects, more acidic in alcoholic cirrhosis, and more alkaline in alcoholic hepatitis. The findings indicate that hepatic metabolite ratios are not a sensitive measure of alcoholic liver disease, that quantitative P-31 MR spectroscopy is able to noninvasively show metabolic changes associated with alcoholic liver disease, and that alcoholic hepatitis and cirrhosis may be distinguished by means of hepatic intracellular pH measured with MR spectroscopy.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalRadiology
Volume173
Issue number2
DOIs
StatePublished - Jan 1 1989

Fingerprint

Alcoholic Liver Diseases
Magnetic Resonance Spectroscopy
Alcoholic Hepatitis
Alcoholic Liver Cirrhosis
Liver
Healthy Volunteers
Hepatitis B
Phosphorus
Hydrogen
Adenosine Triphosphate
Phosphates

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Meyerhoff, D. J., Boska, M. D., Thomas, A. M., & Weiner, M. W. (1989). Alcoholic liver disease: Quantitative image-guided P-31 MR spectroscopy. Radiology, 173(2), 393-400. https://doi.org/10.1148/radiology.173.2.2798871

Alcoholic liver disease : Quantitative image-guided P-31 MR spectroscopy. / Meyerhoff, D. J.; Boska, M. D.; Thomas, A. M.; Weiner, M. W.

In: Radiology, Vol. 173, No. 2, 01.01.1989, p. 393-400.

Research output: Contribution to journalArticle

Meyerhoff, DJ, Boska, MD, Thomas, AM & Weiner, MW 1989, 'Alcoholic liver disease: Quantitative image-guided P-31 MR spectroscopy', Radiology, vol. 173, no. 2, pp. 393-400. https://doi.org/10.1148/radiology.173.2.2798871
Meyerhoff, D. J. ; Boska, M. D. ; Thomas, A. M. ; Weiner, M. W. / Alcoholic liver disease : Quantitative image-guided P-31 MR spectroscopy. In: Radiology. 1989 ; Vol. 173, No. 2. pp. 393-400.
@article{0ac3040deb7f486c97236fbb54f8f890,
title = "Alcoholic liver disease: Quantitative image-guided P-31 MR spectroscopy",
abstract = "Phosphorus-31 magnetic resonance (MR) spectroscopy was performed on the liver of patients with alcoholic hepatitis (n=10), alcoholic cirrhosis (n=9), and viral hepatitis B (n=3) and on healthy control subjects (n=21). A hydrogen-1 MR image-guided localization technique (ISIS) was used to acquire P-31 spectra selectively from a volume of interest within the liver. Spectra were analyzed to yield absolute molar concentrations of hepatic phosphomonoesters, phosphodiesters, inorganic phosphate, and adenosine triphosphate. It was found that (a) hepatic metabolite ratios in alcoholic liver disease were not significantly different from those in healthy subjects, (b) absolute hepatic metabolite concentrations were decreased by 25{\%}-46{\%} in alcoholic hepatitis and 13{\%}-50{\%} in alcoholic cirrhosis compared with those in healthy subjects, and (c) hepatic intracellular pH was 7.4 in healthy subjects, more acidic in alcoholic cirrhosis, and more alkaline in alcoholic hepatitis. The findings indicate that hepatic metabolite ratios are not a sensitive measure of alcoholic liver disease, that quantitative P-31 MR spectroscopy is able to noninvasively show metabolic changes associated with alcoholic liver disease, and that alcoholic hepatitis and cirrhosis may be distinguished by means of hepatic intracellular pH measured with MR spectroscopy.",
author = "Meyerhoff, {D. J.} and Boska, {M. D.} and Thomas, {A. M.} and Weiner, {M. W.}",
year = "1989",
month = "1",
day = "1",
doi = "10.1148/radiology.173.2.2798871",
language = "English (US)",
volume = "173",
pages = "393--400",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - Alcoholic liver disease

T2 - Quantitative image-guided P-31 MR spectroscopy

AU - Meyerhoff, D. J.

AU - Boska, M. D.

AU - Thomas, A. M.

AU - Weiner, M. W.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Phosphorus-31 magnetic resonance (MR) spectroscopy was performed on the liver of patients with alcoholic hepatitis (n=10), alcoholic cirrhosis (n=9), and viral hepatitis B (n=3) and on healthy control subjects (n=21). A hydrogen-1 MR image-guided localization technique (ISIS) was used to acquire P-31 spectra selectively from a volume of interest within the liver. Spectra were analyzed to yield absolute molar concentrations of hepatic phosphomonoesters, phosphodiesters, inorganic phosphate, and adenosine triphosphate. It was found that (a) hepatic metabolite ratios in alcoholic liver disease were not significantly different from those in healthy subjects, (b) absolute hepatic metabolite concentrations were decreased by 25%-46% in alcoholic hepatitis and 13%-50% in alcoholic cirrhosis compared with those in healthy subjects, and (c) hepatic intracellular pH was 7.4 in healthy subjects, more acidic in alcoholic cirrhosis, and more alkaline in alcoholic hepatitis. The findings indicate that hepatic metabolite ratios are not a sensitive measure of alcoholic liver disease, that quantitative P-31 MR spectroscopy is able to noninvasively show metabolic changes associated with alcoholic liver disease, and that alcoholic hepatitis and cirrhosis may be distinguished by means of hepatic intracellular pH measured with MR spectroscopy.

AB - Phosphorus-31 magnetic resonance (MR) spectroscopy was performed on the liver of patients with alcoholic hepatitis (n=10), alcoholic cirrhosis (n=9), and viral hepatitis B (n=3) and on healthy control subjects (n=21). A hydrogen-1 MR image-guided localization technique (ISIS) was used to acquire P-31 spectra selectively from a volume of interest within the liver. Spectra were analyzed to yield absolute molar concentrations of hepatic phosphomonoesters, phosphodiesters, inorganic phosphate, and adenosine triphosphate. It was found that (a) hepatic metabolite ratios in alcoholic liver disease were not significantly different from those in healthy subjects, (b) absolute hepatic metabolite concentrations were decreased by 25%-46% in alcoholic hepatitis and 13%-50% in alcoholic cirrhosis compared with those in healthy subjects, and (c) hepatic intracellular pH was 7.4 in healthy subjects, more acidic in alcoholic cirrhosis, and more alkaline in alcoholic hepatitis. The findings indicate that hepatic metabolite ratios are not a sensitive measure of alcoholic liver disease, that quantitative P-31 MR spectroscopy is able to noninvasively show metabolic changes associated with alcoholic liver disease, and that alcoholic hepatitis and cirrhosis may be distinguished by means of hepatic intracellular pH measured with MR spectroscopy.

UR - http://www.scopus.com/inward/record.url?scp=0024367120&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024367120&partnerID=8YFLogxK

U2 - 10.1148/radiology.173.2.2798871

DO - 10.1148/radiology.173.2.2798871

M3 - Article

C2 - 2798871

AN - SCOPUS:0024367120

VL - 173

SP - 393

EP - 400

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -