Alcoholic Liver Disease

Pathogenesis and Current Management

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Excessive alcohol consumption is a global healthcare problem. The liver sustains the greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol metabolism. Chronic and excessive alcohol consumption produces a wide spectrum of hepatic lesions, the most characteristic of which are steatosis, hepatitis, and fibrosis/cirrhosis. Steatosis is the earliest response to heavy drinking and is characterized by the deposition of fat in hepatocytes. Steatosis can progress to steatohepatitis, which is a more severe, inflammatory type of liver injury. This stage of liver disease can lead to the development of fibrosis, during which there is excessive deposition of extracellular matrix proteins. The fibrotic response begins with active pericellular fibrosis, which may progress to cirrhosis, characterized by excessive liver scarring, vascular alterations, and eventual liver failure. Among problem drinkers, about 35 percent develop advanced liver disease because a number of disease modifiers exacerbate, slow, or prevent alcoholic liver disease progression. There are still no FDA-approved pharmacological or nutritional therapies for treating patients with alcoholic liver disease. Cessation of drinking (i.e., abstinence) is an integral part of therapy. Liver transplantation remains the life-saving strategy for patients with end-stage alcoholic liver disease.

Original languageEnglish (US)
Pages (from-to)147-161
Number of pages15
JournalAlcohol research : current reviews
Volume38
Issue number2
StatePublished - Jan 1 2017

Fingerprint

Alcoholic Liver Diseases
Fibrosis
Drinking
Liver
Alcohol Drinking
Liver Diseases
End Stage Liver Disease
Extracellular Matrix Proteins
Liver Failure
Wounds and Injuries
Fatty Liver
Liver Transplantation
Hepatitis
Cicatrix
Blood Vessels
Disease Progression
Hepatocytes
Ethanol
Fats
Pharmacology

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Alcoholic Liver Disease : Pathogenesis and Current Management. / Osna, Natalia A; Donohue, Terrence; Kharbanda, Kusum.

In: Alcohol research : current reviews, Vol. 38, No. 2, 01.01.2017, p. 147-161.

Research output: Contribution to journalReview article

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