Alcoholic hepatitis.

C. M. Leevy, R. K. Zetterman

Research output: Contribution to journalArticle


Alcoholic hepatitis is the precursor of cirrhosis. Susceptibility is independent of amount and duration of ethanol intake or of diet. Centrilobular hyalin, the key morphologic abnormality, sensitizes lymphocytes to secrete factors which may account (in part) for necrosis, liver cell destruction, increased collagen synthesis and development of cirrhosis. Diagnosis may be facilitated by detection of alcoholic hyalin antigen (AHAg) and antibody (AHAb) in serum of patients with alcoholic hepatitis. Treatment requires abstinence. Steroids have not reduced mortality rates. Measures to improve immunologic reactivity may be helpful. Persons unable to abstain should be enrolled in a surveillance group.

Original languageEnglish (US)
Pages (from-to)60-67
Number of pages8
JournalAmerican Family Physician
Issue number6
StatePublished - Jun 1 1976


ASJC Scopus subject areas

  • Family Practice

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