Alcoholic hepatitis.

C. M. Leevy, Rowen K Zetterman

Research output: Contribution to journalArticle

Abstract

Alcoholic hepatitis is the precursor of cirrhosis. Susceptibility is independent of amount and duration of ethanol intake or of diet. Centrilobular hyalin, the key morphologic abnormality, sensitizes lymphocytes to secrete factors which may account (in part) for necrosis, liver cell destruction, increased collagen synthesis and development of cirrhosis. Diagnosis may be facilitated by detection of alcoholic hyalin antigen (AHAg) and antibody (AHAb) in serum of patients with alcoholic hepatitis. Treatment requires abstinence. Steroids have not reduced mortality rates. Measures to improve immunologic reactivity may be helpful. Persons unable to abstain should be enrolled in a surveillance group.

Original languageEnglish (US)
Pages (from-to)60-67
Number of pages8
JournalAmerican Family Physician
Volume13
Issue number6
StatePublished - Jun 1 1976

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Alcoholic Hepatitis
Hyalin
Fibrosis
Ethanol
Necrosis
Collagen
Steroids
Lymphocytes
Diet
Antigens
Mortality
Antibodies
Liver
Serum
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alcoholic hepatitis. / Leevy, C. M.; Zetterman, Rowen K.

In: American Family Physician, Vol. 13, No. 6, 01.06.1976, p. 60-67.

Research output: Contribution to journalArticle

Leevy, CM & Zetterman, RK 1976, 'Alcoholic hepatitis.', American Family Physician, vol. 13, no. 6, pp. 60-67.
Leevy, C. M. ; Zetterman, Rowen K. / Alcoholic hepatitis. In: American Family Physician. 1976 ; Vol. 13, No. 6. pp. 60-67.
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