Alcohol consumption and chronic atrophic gastritis: Population-based study among 9,444 older adults from Germany

Lei Gao, Melanie N. Weck, Christa Stegmaier, Dietrich Rothenbacher, Hermann Brenner

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Moderate alcohol consumption has been suggested to facilitate elimination of Helicobacter pylori infection which is a key risk factor for chronic atrophic gastritis (CAG) and gastric cancer. The aim of our study was to assess the association of alcohol consumption with CAG among older adults from Germany. In the baseline examination of ESTHER, a population-based study conducted in Saarland, serological measurements of pepsinogen I and II (for CAG definition) and H. pylori antibodies were taken in 9,444 subjects aged 50-74 years. Moderate current (<60 g/week) and lifetime (≤51,376 g, lowest quartile) alcohol consumption were found to be associated with significantly reduced CAG risk compared to alcohol abstinence with adjusted odds ratios of 0.71 (0.55-0.90) and 0.73 (0.55-0.96), respectively. Inverse associations with CAG were observed for moderate alcohol consumption from both beer and wine, and were slightly attenuated after additional adjustment for H. pylori infection. Our results are consistent with the hypothesis that moderate alcohol consumption may be inversely related to CAG, partly through facilitating the elimination of H. pylori. However, the observed patterns suggest that other mechanisms are likely to contribute to the association as well.

Original languageEnglish (US)
Pages (from-to)2918-2922
Number of pages5
JournalInternational Journal of Cancer
Volume125
Issue number12
DOIs
StatePublished - Dec 15 2009

Fingerprint

Atrophic Gastritis
Alcohol Drinking
Germany
Helicobacter pylori
Population
Helicobacter Infections
Pepsinogen C
Alcohol Abstinence
Pepsinogen A
Wine
Stomach Neoplasms
Odds Ratio
Antibodies

Keywords

  • Alcohol consumption
  • Chronic atrophic gastritis
  • Helicobacter pylori

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Alcohol consumption and chronic atrophic gastritis : Population-based study among 9,444 older adults from Germany. / Gao, Lei; Weck, Melanie N.; Stegmaier, Christa; Rothenbacher, Dietrich; Brenner, Hermann.

In: International Journal of Cancer, Vol. 125, No. 12, 15.12.2009, p. 2918-2922.

Research output: Contribution to journalArticle

Gao, Lei ; Weck, Melanie N. ; Stegmaier, Christa ; Rothenbacher, Dietrich ; Brenner, Hermann. / Alcohol consumption and chronic atrophic gastritis : Population-based study among 9,444 older adults from Germany. In: International Journal of Cancer. 2009 ; Vol. 125, No. 12. pp. 2918-2922.
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