Alcohol and Apoptosis

Benita L McVicker, Dean J. Tuma, Amin A. Naji, Carol A Casey

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter describes the relationship between alcohol-induced apoptosis and liver function. Alcohol abuse and/or dependence are related to many major medical problems and the chronic consumption of ethanol has been associated with an increased risk of stroke, cancer, osteoporosis, lung infections, neurological changes, and the development of alcoholic liver disease. Although much has been learned about the medical symptoms associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects. One particular cellular event that is observed in alcohol-induced diseases that may contribute to adverse pathology is the increased production and subsequent accumulation of apoptotic cells. Apoptosis is an active and highly regulated mode of cell death, which in a healthy organ helps to maintain tissue homeostasis. However, when apoptotic death factors are inappropriately expressed because of the introduction of a pathological stimulus such as alcohol, deleterious effects to the organism may occur. Moreover, if the production of apoptotic cells becomes large enough to overwhelm the protection obtained from dead cell removal, a loss of tissue organization and organ viability may occur.

Original languageEnglish (US)
Title of host publicationComprehensive Handbook of Alcohol Related Pathology
PublisherElsevier Inc.
Pages1175-1193
Number of pages19
Volume3-3
ISBN (Electronic)9780080502311
ISBN (Print)9780125643702
DOIs
StatePublished - Jan 1 2005

Fingerprint

Alcohols
Apoptosis
Tissue Survival
Alcoholism
Ethanol
Liver
Tissue homeostasis
Alcoholic Liver Diseases
Cells
Osteoporosis
Pathology
Cell death
Lung Neoplasms
Medical problems
Homeostasis
Cell Death
Stroke
Tissue
Infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

McVicker, B. L., Tuma, D. J., Naji, A. A., & Casey, C. A. (2005). Alcohol and Apoptosis. In Comprehensive Handbook of Alcohol Related Pathology (Vol. 3-3, pp. 1175-1193). Elsevier Inc.. https://doi.org/10.1016/B978-012564370-2/50092-1

Alcohol and Apoptosis. / McVicker, Benita L; Tuma, Dean J.; Naji, Amin A.; Casey, Carol A.

Comprehensive Handbook of Alcohol Related Pathology. Vol. 3-3 Elsevier Inc., 2005. p. 1175-1193.

Research output: Chapter in Book/Report/Conference proceedingChapter

McVicker, BL, Tuma, DJ, Naji, AA & Casey, CA 2005, Alcohol and Apoptosis. in Comprehensive Handbook of Alcohol Related Pathology. vol. 3-3, Elsevier Inc., pp. 1175-1193. https://doi.org/10.1016/B978-012564370-2/50092-1
McVicker BL, Tuma DJ, Naji AA, Casey CA. Alcohol and Apoptosis. In Comprehensive Handbook of Alcohol Related Pathology. Vol. 3-3. Elsevier Inc. 2005. p. 1175-1193 https://doi.org/10.1016/B978-012564370-2/50092-1
McVicker, Benita L ; Tuma, Dean J. ; Naji, Amin A. ; Casey, Carol A. / Alcohol and Apoptosis. Comprehensive Handbook of Alcohol Related Pathology. Vol. 3-3 Elsevier Inc., 2005. pp. 1175-1193
@inbook{737adaf519374dd38c5ab2c84dca11b5,
title = "Alcohol and Apoptosis",
abstract = "This chapter describes the relationship between alcohol-induced apoptosis and liver function. Alcohol abuse and/or dependence are related to many major medical problems and the chronic consumption of ethanol has been associated with an increased risk of stroke, cancer, osteoporosis, lung infections, neurological changes, and the development of alcoholic liver disease. Although much has been learned about the medical symptoms associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects. One particular cellular event that is observed in alcohol-induced diseases that may contribute to adverse pathology is the increased production and subsequent accumulation of apoptotic cells. Apoptosis is an active and highly regulated mode of cell death, which in a healthy organ helps to maintain tissue homeostasis. However, when apoptotic death factors are inappropriately expressed because of the introduction of a pathological stimulus such as alcohol, deleterious effects to the organism may occur. Moreover, if the production of apoptotic cells becomes large enough to overwhelm the protection obtained from dead cell removal, a loss of tissue organization and organ viability may occur.",
author = "McVicker, {Benita L} and Tuma, {Dean J.} and Naji, {Amin A.} and Casey, {Carol A}",
year = "2005",
month = "1",
day = "1",
doi = "10.1016/B978-012564370-2/50092-1",
language = "English (US)",
isbn = "9780125643702",
volume = "3-3",
pages = "1175--1193",
booktitle = "Comprehensive Handbook of Alcohol Related Pathology",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Alcohol and Apoptosis

AU - McVicker, Benita L

AU - Tuma, Dean J.

AU - Naji, Amin A.

AU - Casey, Carol A

PY - 2005/1/1

Y1 - 2005/1/1

N2 - This chapter describes the relationship between alcohol-induced apoptosis and liver function. Alcohol abuse and/or dependence are related to many major medical problems and the chronic consumption of ethanol has been associated with an increased risk of stroke, cancer, osteoporosis, lung infections, neurological changes, and the development of alcoholic liver disease. Although much has been learned about the medical symptoms associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects. One particular cellular event that is observed in alcohol-induced diseases that may contribute to adverse pathology is the increased production and subsequent accumulation of apoptotic cells. Apoptosis is an active and highly regulated mode of cell death, which in a healthy organ helps to maintain tissue homeostasis. However, when apoptotic death factors are inappropriately expressed because of the introduction of a pathological stimulus such as alcohol, deleterious effects to the organism may occur. Moreover, if the production of apoptotic cells becomes large enough to overwhelm the protection obtained from dead cell removal, a loss of tissue organization and organ viability may occur.

AB - This chapter describes the relationship between alcohol-induced apoptosis and liver function. Alcohol abuse and/or dependence are related to many major medical problems and the chronic consumption of ethanol has been associated with an increased risk of stroke, cancer, osteoporosis, lung infections, neurological changes, and the development of alcoholic liver disease. Although much has been learned about the medical symptoms associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects. One particular cellular event that is observed in alcohol-induced diseases that may contribute to adverse pathology is the increased production and subsequent accumulation of apoptotic cells. Apoptosis is an active and highly regulated mode of cell death, which in a healthy organ helps to maintain tissue homeostasis. However, when apoptotic death factors are inappropriately expressed because of the introduction of a pathological stimulus such as alcohol, deleterious effects to the organism may occur. Moreover, if the production of apoptotic cells becomes large enough to overwhelm the protection obtained from dead cell removal, a loss of tissue organization and organ viability may occur.

UR - http://www.scopus.com/inward/record.url?scp=84943270491&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943270491&partnerID=8YFLogxK

U2 - 10.1016/B978-012564370-2/50092-1

DO - 10.1016/B978-012564370-2/50092-1

M3 - Chapter

AN - SCOPUS:84943270491

SN - 9780125643702

VL - 3-3

SP - 1175

EP - 1193

BT - Comprehensive Handbook of Alcohol Related Pathology

PB - Elsevier Inc.

ER -