Airway inflammation

James H. Shelhamer, Stewart J. Levine, Tong Wu, David B. Jacoby, Michael A. Kaliner, Stephen I. Rennard

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Diseases characterized by airway inflammation, excessive airway secretion, and airway obstruction affect a substantial proportion of the population. These diseases include asthma, chronic bronchitis, bronchiectasis, and cystic fibrosis. Asthma and chronic bronchitis may affect 25 million persons in the United States. Much progress has been made in the last decade toward an understanding of the mechanisms underlying chronic airway inflammation; recent work has resulted in several new concepts of the initiation and maintenance of airway inflammation. Airway production of chemokines, cytokines, and growth factors in response to irritants, infectious agents, and inflammatory mediators may play an important role in the modulation of acute and chronic airway inflammation. Lipid mediators may be produced by resident airway cells and by inflammatory cells; production of these mediators may also be altered by inflammatory cytokines. Increased airway obstruction may be related to intercurrent viral respiratory infection and to the induction of airway inflammation and airway hyperreactivity that results from such infection. Furthermore, several models exist to explain the processes by which airway inflammation is perpetuated in diseases such as asthma and chronic bronchitis. These include neurogenic inflammation, the perpetuation of the acute inflammatory response, and cycles of airway epithelial cell-mediated and inflammatory cell-mediated recruitment and activation of inflammatory cells. An understanding of these mechanisms of airway inflammation may provide the clinician with new therapeutic approaches to the treatment of these common and chronic diseases.

Original languageEnglish (US)
Pages (from-to)288-304
Number of pages17
JournalAnnals of internal medicine
Volume123
Issue number4
DOIs
StatePublished - Aug 15 1995

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Inflammation
Chronic Bronchitis
Asthma
Airway Obstruction
Neurogenic Inflammation
Cytokines
Bronchiectasis
Irritants
Virus Diseases
Chemokines
Cystic Fibrosis
Respiratory Tract Infections
Intercellular Signaling Peptides and Proteins
Chronic Disease
Epithelial Cells
Maintenance
Lipids
Infection
Population
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Shelhamer, J. H., Levine, S. J., Wu, T., Jacoby, D. B., Kaliner, M. A., & Rennard, S. I. (1995). Airway inflammation. Annals of internal medicine, 123(4), 288-304. https://doi.org/10.7326/0003-4819-123-4-199508150-00008

Airway inflammation. / Shelhamer, James H.; Levine, Stewart J.; Wu, Tong; Jacoby, David B.; Kaliner, Michael A.; Rennard, Stephen I.

In: Annals of internal medicine, Vol. 123, No. 4, 15.08.1995, p. 288-304.

Research output: Contribution to journalArticle

Shelhamer, JH, Levine, SJ, Wu, T, Jacoby, DB, Kaliner, MA & Rennard, SI 1995, 'Airway inflammation', Annals of internal medicine, vol. 123, no. 4, pp. 288-304. https://doi.org/10.7326/0003-4819-123-4-199508150-00008
Shelhamer JH, Levine SJ, Wu T, Jacoby DB, Kaliner MA, Rennard SI. Airway inflammation. Annals of internal medicine. 1995 Aug 15;123(4):288-304. https://doi.org/10.7326/0003-4819-123-4-199508150-00008
Shelhamer, James H. ; Levine, Stewart J. ; Wu, Tong ; Jacoby, David B. ; Kaliner, Michael A. ; Rennard, Stephen I. / Airway inflammation. In: Annals of internal medicine. 1995 ; Vol. 123, No. 4. pp. 288-304.
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