AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs

Margaret V. Ragni, Steven H. Belle, Ronald Jaffe, Joseph Locker, Sandra L. Duerstein, Debra C. Bass, Joseph E. Addiego, Louis M. Aledort, Lloyd E. Barron, Doreen B. Brettler, George R. Buchanan, Joan C. Gill, Bruce M. Ewenstein, David Green, Margaret W. Hilgartner, W. Keith Hoots, C. Thomas Kisker, Everett W. Lovrien, Cynthia J. Rutherford, Natalie L. SandersKenneth J. Smith, Sally P. Stabler, Susan Swindells, Gilbert C. White, Lawrence A. Kingsley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We studied the characteristics and temporal trends of AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) in individuals with hemophilia. Prospective data were collected on 33 HIV-positive hemophiliacs with AIDS-NHL enrolled in the Hemophilia Malignancy Study (HMS), of whom 21 had primary and 12 had secondary or subsequent AIDS-defining illnesses, and analyzed for frequency and temporal trends. As compared with primary AIDS-NHL, secondary AIDS-NHL occurred at an older mean age, 37 versus 29 years (p =0.12); at a lower mean CD4 count, 46 versus 154 (p = 0.07); after a longer period of immunosuppression (CD4 < 200/μl), 41 versus 16 months (p = 0.03); and with shorter median survival, 2 versus 7 months (p = 0.09). The presence of EBV in tumor tissue was associated with shorter survival, 1 versus 7 months (p = 0.17). Between 1981 and 1988 and 1989 and 1994, the proportion of primary AIDS diagnoses that were AIDS-NHL changed minimally, 4.6 versus 6.1%, whereas there were significant decreases in Pneumocystis carinii pneumonia (PCP, p = 0.02) and wasting (p = 0.07), and an increase in Candida (p = 0.004). These findings confirm that an increasing proportion of AIDS-NHL in hemophiliacs are occurring as secondary or later AIDS diagnoses, and they are associated with prolonged duration of immunosuppression.

Original languageEnglish (US)
Pages (from-to)78-86
Number of pages9
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume13
Issue number1
DOIs
StatePublished - Jan 1 1996

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AIDS-Related Lymphoma
Non-Hodgkin's Lymphoma
Acquired Immunodeficiency Syndrome
Hemophilia A
Immunosuppression
Pneumocystis Pneumonia
Delayed Diagnosis
CD4 Lymphocyte Count
Human Herpesvirus 4
Candida
Neoplasms
HIV

Keywords

  • AIDS
  • Hemophilia
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs. / Ragni, Margaret V.; Belle, Steven H.; Jaffe, Ronald; Locker, Joseph; Duerstein, Sandra L.; Bass, Debra C.; Addiego, Joseph E.; Aledort, Louis M.; Barron, Lloyd E.; Brettler, Doreen B.; Buchanan, George R.; Gill, Joan C.; Ewenstein, Bruce M.; Green, David; Hilgartner, Margaret W.; Hoots, W. Keith; Kisker, C. Thomas; Lovrien, Everett W.; Rutherford, Cynthia J.; Sanders, Natalie L.; Smith, Kenneth J.; Stabler, Sally P.; Swindells, Susan; White, Gilbert C.; Kingsley, Lawrence A.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 13, No. 1, 01.01.1996, p. 78-86.

Research output: Contribution to journalArticle

Ragni, MV, Belle, SH, Jaffe, R, Locker, J, Duerstein, SL, Bass, DC, Addiego, JE, Aledort, LM, Barron, LE, Brettler, DB, Buchanan, GR, Gill, JC, Ewenstein, BM, Green, D, Hilgartner, MW, Hoots, WK, Kisker, CT, Lovrien, EW, Rutherford, CJ, Sanders, NL, Smith, KJ, Stabler, SP, Swindells, S, White, GC & Kingsley, LA 1996, 'AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 13, no. 1, pp. 78-86. https://doi.org/10.1097/00042560-199609000-00011
Ragni, Margaret V. ; Belle, Steven H. ; Jaffe, Ronald ; Locker, Joseph ; Duerstein, Sandra L. ; Bass, Debra C. ; Addiego, Joseph E. ; Aledort, Louis M. ; Barron, Lloyd E. ; Brettler, Doreen B. ; Buchanan, George R. ; Gill, Joan C. ; Ewenstein, Bruce M. ; Green, David ; Hilgartner, Margaret W. ; Hoots, W. Keith ; Kisker, C. Thomas ; Lovrien, Everett W. ; Rutherford, Cynthia J. ; Sanders, Natalie L. ; Smith, Kenneth J. ; Stabler, Sally P. ; Swindells, Susan ; White, Gilbert C. ; Kingsley, Lawrence A. / AIDS-associated non-Hodgkin's lymphomas as primary and secondary AIDS diagnoses in hemophiliacs. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1996 ; Vol. 13, No. 1. pp. 78-86.
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AU - Belle, Steven H.

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AU - Locker, Joseph

AU - Duerstein, Sandra L.

AU - Bass, Debra C.

AU - Addiego, Joseph E.

AU - Aledort, Louis M.

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AU - Gill, Joan C.

AU - Ewenstein, Bruce M.

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AU - Hilgartner, Margaret W.

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AU - Kisker, C. Thomas

AU - Lovrien, Everett W.

AU - Rutherford, Cynthia J.

AU - Sanders, Natalie L.

AU - Smith, Kenneth J.

AU - Stabler, Sally P.

AU - Swindells, Susan

AU - White, Gilbert C.

AU - Kingsley, Lawrence A.

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