AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4

Anapatricia García, Nagadenahalli B. Siddappa, Qingsheng Li, Ashley T. Haase, Katherine Paul, Fawn Stroud, Xiaodong Zhang, Jack A. Fountain, François Villinger, Francis J. Novembre, James G. Else, W. Evan Secor, Ruth M. Ruprecht

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4+ T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.

Original languageEnglish (US)
Pages (from-to)356-360
Number of pages5
JournalJournal of medical primatology
Volume39
Issue number5
DOIs
StatePublished - Oct 1 2010

Fingerprint

Optic Neuritis
Macaca mulatta
optics
Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
blindness
Viremia
viremia
Opportunistic Infections
Human immunodeficiency virus
Blindness
Optic Nerve
infection
necropsy
tropics
nerve tissue
T-lymphocytes
HIV
cells
Pathology

Keywords

  • NeuroAIDS
  • Optic neuropathy
  • R5 SHIV

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4. / García, Anapatricia; Siddappa, Nagadenahalli B.; Li, Qingsheng; Haase, Ashley T.; Paul, Katherine; Stroud, Fawn; Zhang, Xiaodong; Fountain, Jack A.; Villinger, François; Novembre, Francis J.; Else, James G.; Evan Secor, W.; Ruprecht, Ruth M.

In: Journal of medical primatology, Vol. 39, No. 5, 01.10.2010, p. 356-360.

Research output: Contribution to journalArticle

García, A, Siddappa, NB, Li, Q, Haase, AT, Paul, K, Stroud, F, Zhang, X, Fountain, JA, Villinger, F, Novembre, FJ, Else, JG, Evan Secor, W & Ruprecht, RM 2010, 'AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4', Journal of medical primatology, vol. 39, no. 5, pp. 356-360. https://doi.org/10.1111/j.1600-0684.2010.00416.x
García, Anapatricia ; Siddappa, Nagadenahalli B. ; Li, Qingsheng ; Haase, Ashley T. ; Paul, Katherine ; Stroud, Fawn ; Zhang, Xiaodong ; Fountain, Jack A. ; Villinger, François ; Novembre, Francis J. ; Else, James G. ; Evan Secor, W. ; Ruprecht, Ruth M. / AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4. In: Journal of medical primatology. 2010 ; Vol. 39, No. 5. pp. 356-360.
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