AIDS and associated malignancies

Charles Wood, William Harrington

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

AIDS associated malignancies (ARL) is a major complication associated with AIDS patients upon immunosuppression. Chronically immunocompromised patients have a markedly increased risk of developing lymphoproliferative disease. In the era of potent antiretrovirals therapy (ARV), the malignant complications due to HIV-1 infection have decreased in developed nations where ARV is administered, but still poses a major problem in developing countries where HIV-1 incidence is high and ARV is still not yet widely available. Even in ARV treated individuals there is a concern that the prolonged survival of many HIV-1 carriers is likely to eventually result in an increased number of malignancies diagnosed. Malignancies that were found to have high incidence in HIV-infected individuals are Kaposi's sarcoma (KS), Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). The incidence of NHL has increased nearly 200 fold in HIV-positive patients, and accounts for a greater percentage of AIDS defining illness in the US and Europe since the advent of HAART therapy. These AIDS related lymphomas are distinct from their counterparts seen in HIV-1 seronegative patients. For example nearly half of all cases of ARL are associated with the presence of a gamma herpesvirus, Epstein Barr virus (EBV) or human herpesvirus-8 (HHV-8)/ Kaposi's sarcoma associated herpesvirus (KSHV). The pathogenesis of ARLs is complex. B-cell proliferation driven by chronic antigenemia resulting in the induction of polyclonal and ultimately monoclonal lymphoproliferation may occur in the setting of severe immunosuppression.

Original languageEnglish (US)
Pages (from-to)947-952
Number of pages6
JournalCell Research
Volume15
Issue number11-12
DOIs
StatePublished - Dec 29 2005

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Acquired Immunodeficiency Syndrome
HIV-1
Human Herpesvirus 8
Neoplasms
Non-Hodgkin's Lymphoma
Immunosuppression
Incidence
AIDS-Related Lymphoma
HIV
Therapeutics
Kaposi's Sarcoma
Herpesviridae
Highly Active Antiretroviral Therapy
Immunocompromised Host
Human Herpesvirus 4
Hodgkin Disease
Developed Countries
Developing Countries
HIV Infections
B-Lymphocytes

Keywords

  • Epstein-Barr virus
  • Human herpesvirus 8
  • KS-associated herpesvirus
  • Kaposi's sarcoma
  • Lymphomas

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

AIDS and associated malignancies. / Wood, Charles; Harrington, William.

In: Cell Research, Vol. 15, No. 11-12, 29.12.2005, p. 947-952.

Research output: Contribution to journalReview article

Wood, C & Harrington, W 2005, 'AIDS and associated malignancies', Cell Research, vol. 15, no. 11-12, pp. 947-952. https://doi.org/10.1038/sj.cr.7290372
Wood, Charles ; Harrington, William. / AIDS and associated malignancies. In: Cell Research. 2005 ; Vol. 15, No. 11-12. pp. 947-952.
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