Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma

Brian C.H. Chiu, Bhavana J Dave, Aaron Blair, Susan M. Gapstur, Shelia Hoar Zahm, Dennis D. Weisenburger

Research output: Contribution to journalArticle

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Abstract

Pesticides have been specifically associated with the t(14;18)(q32;q21) chromosomal translocation. To investigate whether the association between pesticides and risk of non-Hodgkin lymphoma (NHL) differs for molecular subtypes of NHL defined by t(14;18) status, we obtained 175 tumor blocks from case subjects in a population-based case-control study conducted in Nebraska between 1983 and 1986. The t(14;18) was determined by interphase fluorescence in situ hybridization in 172 of 175 tumor blocks. We compared exposures to insecticides, herbicides, fungicides, and fumigants in 65 t(14;18)-positive and 107 t(14;18)-negative case subjects with those among 1432 control subjects. Multivariate polytomous logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Compared with farmers who never used pesticides, the risk of t(14;18)-positive NHLwas significantly elevated among farmerswhoused animal insecticides (OR = 2.6; 95%CI, 1.0-6.9), crop insecticides (OR = 3.0; 95% CI, 1.1-8.2), herbicides (OR = 2.9; 95% CI, 1.1-7.9), and fumigants (OR = 5.0; 95% CI, 1.7-14.5). None of these pesticides were associated with t(14;18)-negative NHL. The risk of t(14;18)-positive NHL associated with insecticides and herbicides increased with longer duration of use. We conclude that insecticides, herbicides, and fumigants were associated with risk of t(14;18)-positive NHL but not t(14;18)-negative NHL. These results suggest that defining subsets of NHL according to t(14;18) status is a useful approach for etiologic research.

Original languageEnglish (US)
Pages (from-to)1363-1369
Number of pages7
JournalBlood
Volume108
Issue number4
DOIs
StatePublished - Aug 15 2006

Fingerprint

Insecticides
Pesticides
Non-Hodgkin's Lymphoma
Herbicides
Odds Ratio
Confidence Intervals
Tumors
Fungicides
Crops
Genetic Translocation
Logistics
Animals
Interphase
Fluorescence
Fluorescence In Situ Hybridization
Case-Control Studies
Neoplasms
Logistic Models
Research
Population

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Chiu, B. C. H., Dave, B. J., Blair, A., Gapstur, S. M., Zahm, S. H., & Weisenburger, D. D. (2006). Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma. Blood, 108(4), 1363-1369. https://doi.org/10.1182/blood-2005-12-008755

Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma. / Chiu, Brian C.H.; Dave, Bhavana J; Blair, Aaron; Gapstur, Susan M.; Zahm, Shelia Hoar; Weisenburger, Dennis D.

In: Blood, Vol. 108, No. 4, 15.08.2006, p. 1363-1369.

Research output: Contribution to journalArticle

Chiu, BCH, Dave, BJ, Blair, A, Gapstur, SM, Zahm, SH & Weisenburger, DD 2006, 'Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma', Blood, vol. 108, no. 4, pp. 1363-1369. https://doi.org/10.1182/blood-2005-12-008755
Chiu, Brian C.H. ; Dave, Bhavana J ; Blair, Aaron ; Gapstur, Susan M. ; Zahm, Shelia Hoar ; Weisenburger, Dennis D. / Agricultural pesticide use and risk of t(14;18)-defined subtypes of non-Hodgkin lymphoma. In: Blood. 2006 ; Vol. 108, No. 4. pp. 1363-1369.
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abstract = "Pesticides have been specifically associated with the t(14;18)(q32;q21) chromosomal translocation. To investigate whether the association between pesticides and risk of non-Hodgkin lymphoma (NHL) differs for molecular subtypes of NHL defined by t(14;18) status, we obtained 175 tumor blocks from case subjects in a population-based case-control study conducted in Nebraska between 1983 and 1986. The t(14;18) was determined by interphase fluorescence in situ hybridization in 172 of 175 tumor blocks. We compared exposures to insecticides, herbicides, fungicides, and fumigants in 65 t(14;18)-positive and 107 t(14;18)-negative case subjects with those among 1432 control subjects. Multivariate polytomous logistic regression was used to calculate odds ratios (ORs) and 95{\%} confidence intervals (CIs). Compared with farmers who never used pesticides, the risk of t(14;18)-positive NHLwas significantly elevated among farmerswhoused animal insecticides (OR = 2.6; 95{\%}CI, 1.0-6.9), crop insecticides (OR = 3.0; 95{\%} CI, 1.1-8.2), herbicides (OR = 2.9; 95{\%} CI, 1.1-7.9), and fumigants (OR = 5.0; 95{\%} CI, 1.7-14.5). None of these pesticides were associated with t(14;18)-negative NHL. The risk of t(14;18)-positive NHL associated with insecticides and herbicides increased with longer duration of use. We conclude that insecticides, herbicides, and fumigants were associated with risk of t(14;18)-positive NHL but not t(14;18)-negative NHL. These results suggest that defining subsets of NHL according to t(14;18) status is a useful approach for etiologic research.",
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