Agricultural pesticide use and risk of glioma in Nebraska, United States

W. J. Lee, J. S. Colt, E. F. Heineman, Rodney D McComb, D. D. Weisenburger, W. Lijinsky, M. H. Ward

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Background: To evaluate the risk of the adult glioma associated with farming and agricultural pesticide use, the authors conducted a population based case control study in eastern Nebraska. Methods: Telephone interviews were conducted with men and women diagnosed with gliomas (n = 251) between 1988 and 1993 and controls (n = 498) randomly selected from the same geographical area. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) for farming and for use of individual and chemical classes of insecticides and herbicides, including pesticides classified as nitrosatable (able to form N-nitroso compounds upon reaction with nitrite). Non-farmers were used as the reference category for all analyses. Results: Among men, ever living or working on a farm and duration of farming were associated with significantly increased risks of glioma (≥55 years on a farm OR = 3.9, 95% CI 1.8 to 8.6); however, positive findings were limited to proxy respondents. Among women, there were no positive associations with farming activities among self or proxy respondents. Specific pesticide families and individual pesticides were associated with significantly increased risks among male farmers; however, most of the positive associations were limited to proxy respondents. For two herbicides and three insecticides, use was positively associated with risk among both self and proxy respondents. Based on a small number of exposed cases, ORs were significantly increased for the herbicides metribuzin (OR = 3.4, 95% CI 1.2 to 9.7) and paraquat (OR = 11.1, 95% CI 1.2 to 101), and for the insecticides bufencarb (OR = 18.9, 95% CI 1.9 to 187), chlorpyrifos (OR = 22.6, 95% CI 2.7 to 191), and coumaphos (OR = 5.9, 95% CI 1.1 to 32). Conclusion: The authors found significant associations between some specific agricultural pesticide exposures and the risk of glioma among male farmers but not among female farmers in Nebraska; however, most of the positive associations were limited to proxy respondents. These findings warrant further evaluation in prospective cohort studies where issues of recall bias are not a concern.

Original languageEnglish (US)
Pages (from-to)786-792
Number of pages7
JournalOccupational and Environmental Medicine
Volume62
Issue number11
DOIs
StatePublished - Nov 1 2005

Fingerprint

Pesticides
Glioma
pesticide
Odds Ratio
Proxy
insecticide
herbicide
Agriculture
Herbicides
Insecticides
metribuzin
farm
paraquat
chlorpyrifos
Coumaphos
nitrite
Nitroso Compounds
logistics
Chlorpyrifos
Paraquat

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Lee, W. J., Colt, J. S., Heineman, E. F., McComb, R. D., Weisenburger, D. D., Lijinsky, W., & Ward, M. H. (2005). Agricultural pesticide use and risk of glioma in Nebraska, United States. Occupational and Environmental Medicine, 62(11), 786-792. https://doi.org/10.1136/oem.2005.020230

Agricultural pesticide use and risk of glioma in Nebraska, United States. / Lee, W. J.; Colt, J. S.; Heineman, E. F.; McComb, Rodney D; Weisenburger, D. D.; Lijinsky, W.; Ward, M. H.

In: Occupational and Environmental Medicine, Vol. 62, No. 11, 01.11.2005, p. 786-792.

Research output: Contribution to journalArticle

Lee, WJ, Colt, JS, Heineman, EF, McComb, RD, Weisenburger, DD, Lijinsky, W & Ward, MH 2005, 'Agricultural pesticide use and risk of glioma in Nebraska, United States', Occupational and Environmental Medicine, vol. 62, no. 11, pp. 786-792. https://doi.org/10.1136/oem.2005.020230
Lee, W. J. ; Colt, J. S. ; Heineman, E. F. ; McComb, Rodney D ; Weisenburger, D. D. ; Lijinsky, W. ; Ward, M. H. / Agricultural pesticide use and risk of glioma in Nebraska, United States. In: Occupational and Environmental Medicine. 2005 ; Vol. 62, No. 11. pp. 786-792.
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abstract = "Background: To evaluate the risk of the adult glioma associated with farming and agricultural pesticide use, the authors conducted a population based case control study in eastern Nebraska. Methods: Telephone interviews were conducted with men and women diagnosed with gliomas (n = 251) between 1988 and 1993 and controls (n = 498) randomly selected from the same geographical area. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) for farming and for use of individual and chemical classes of insecticides and herbicides, including pesticides classified as nitrosatable (able to form N-nitroso compounds upon reaction with nitrite). Non-farmers were used as the reference category for all analyses. Results: Among men, ever living or working on a farm and duration of farming were associated with significantly increased risks of glioma (≥55 years on a farm OR = 3.9, 95{\%} CI 1.8 to 8.6); however, positive findings were limited to proxy respondents. Among women, there were no positive associations with farming activities among self or proxy respondents. Specific pesticide families and individual pesticides were associated with significantly increased risks among male farmers; however, most of the positive associations were limited to proxy respondents. For two herbicides and three insecticides, use was positively associated with risk among both self and proxy respondents. Based on a small number of exposed cases, ORs were significantly increased for the herbicides metribuzin (OR = 3.4, 95{\%} CI 1.2 to 9.7) and paraquat (OR = 11.1, 95{\%} CI 1.2 to 101), and for the insecticides bufencarb (OR = 18.9, 95{\%} CI 1.9 to 187), chlorpyrifos (OR = 22.6, 95{\%} CI 2.7 to 191), and coumaphos (OR = 5.9, 95{\%} CI 1.1 to 32). Conclusion: The authors found significant associations between some specific agricultural pesticide exposures and the risk of glioma among male farmers but not among female farmers in Nebraska; however, most of the positive associations were limited to proxy respondents. These findings warrant further evaluation in prospective cohort studies where issues of recall bias are not a concern.",
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N2 - Background: To evaluate the risk of the adult glioma associated with farming and agricultural pesticide use, the authors conducted a population based case control study in eastern Nebraska. Methods: Telephone interviews were conducted with men and women diagnosed with gliomas (n = 251) between 1988 and 1993 and controls (n = 498) randomly selected from the same geographical area. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) for farming and for use of individual and chemical classes of insecticides and herbicides, including pesticides classified as nitrosatable (able to form N-nitroso compounds upon reaction with nitrite). Non-farmers were used as the reference category for all analyses. Results: Among men, ever living or working on a farm and duration of farming were associated with significantly increased risks of glioma (≥55 years on a farm OR = 3.9, 95% CI 1.8 to 8.6); however, positive findings were limited to proxy respondents. Among women, there were no positive associations with farming activities among self or proxy respondents. Specific pesticide families and individual pesticides were associated with significantly increased risks among male farmers; however, most of the positive associations were limited to proxy respondents. For two herbicides and three insecticides, use was positively associated with risk among both self and proxy respondents. Based on a small number of exposed cases, ORs were significantly increased for the herbicides metribuzin (OR = 3.4, 95% CI 1.2 to 9.7) and paraquat (OR = 11.1, 95% CI 1.2 to 101), and for the insecticides bufencarb (OR = 18.9, 95% CI 1.9 to 187), chlorpyrifos (OR = 22.6, 95% CI 2.7 to 191), and coumaphos (OR = 5.9, 95% CI 1.1 to 32). Conclusion: The authors found significant associations between some specific agricultural pesticide exposures and the risk of glioma among male farmers but not among female farmers in Nebraska; however, most of the positive associations were limited to proxy respondents. These findings warrant further evaluation in prospective cohort studies where issues of recall bias are not a concern.

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