Agitation by suffocation: How hypoxia activates innate immunity via the warburg effect

Haitao Wen, Jenny P.Y. Ting

Research output: Contribution to journalShort survey

6 Scopus citations

Abstract

A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1α, leading to activation of the proinflammatory cytokine IL-1β.

Original languageEnglish (US)
Pages (from-to)814-815
Number of pages2
JournalCell Metabolism
Volume17
Issue number6
DOIs
StatePublished - Jun 4 2013

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ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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