Agitation by suffocation

How hypoxia activates innate immunity via the warburg effect

Haitao Wen, Jenny P.Y. Ting

Research output: Contribution to journalShort survey

5 Citations (Scopus)

Abstract

A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1α, leading to activation of the proinflammatory cytokine IL-1β.

Original languageEnglish (US)
Pages (from-to)814-815
Number of pages2
JournalCell Metabolism
Volume17
Issue number6
DOIs
StatePublished - Jun 4 2013

Fingerprint

Citric Acid Cycle
Asphyxia
Succinic Acid
Interleukin-1
Innate Immunity
Transcription Factors
Macrophages
Cytokines
Hypoxia

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Agitation by suffocation : How hypoxia activates innate immunity via the warburg effect. / Wen, Haitao; Ting, Jenny P.Y.

In: Cell Metabolism, Vol. 17, No. 6, 04.06.2013, p. 814-815.

Research output: Contribution to journalShort survey

Wen, Haitao ; Ting, Jenny P.Y. / Agitation by suffocation : How hypoxia activates innate immunity via the warburg effect. In: Cell Metabolism. 2013 ; Vol. 17, No. 6. pp. 814-815.
@article{5162043acf8048c7b7b869789983f986,
title = "Agitation by suffocation: How hypoxia activates innate immunity via the warburg effect",
abstract = "A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1α, leading to activation of the proinflammatory cytokine IL-1β.",
author = "Haitao Wen and Ting, {Jenny P.Y.}",
year = "2013",
month = "6",
day = "4",
doi = "10.1016/j.cmet.2013.05.016",
language = "English (US)",
volume = "17",
pages = "814--815",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Agitation by suffocation

T2 - How hypoxia activates innate immunity via the warburg effect

AU - Wen, Haitao

AU - Ting, Jenny P.Y.

PY - 2013/6/4

Y1 - 2013/6/4

N2 - A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1α, leading to activation of the proinflammatory cytokine IL-1β.

AB - A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1α, leading to activation of the proinflammatory cytokine IL-1β.

UR - http://www.scopus.com/inward/record.url?scp=84878775640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878775640&partnerID=8YFLogxK

U2 - 10.1016/j.cmet.2013.05.016

DO - 10.1016/j.cmet.2013.05.016

M3 - Short survey

VL - 17

SP - 814

EP - 815

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 6

ER -