Age-related changes in naive and memory CD4+ T cells in healthy human children

Samuel Jay Pirruccello, Michaeleen Collins, Janet E. Wilson, Bruce M. McManus

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Subsets of CD4+ T cells originally identified functionally as suppressor-inducer and helper-inducer populations have recently been reinterpreted as naive and memory maturational states. The subsets can be identified by the surface expression of CD45R and CDw29, respectively. Using two-color flow cytometric analysis, we measured these CD4+ T cell subsets in two samples of cord blood and in 26 healthy children between the ages of 1 and 19 years. As has been reported by others, we observed that the majority of CD4+ T cells in cord blood consist predominantly of the CD45R+ subset. With aging we could demonstrate a gradual acquisition of CDw29+, CD4+ T cells and a concomitant gradual decrease in the percentage of CD45R+, CD4+ T cells. These age-related changes are consistent with the concept of naive (CD45R+) and memory (CDw29+) subsets. Further, because of the dynamic changes, their utilization as prognostic indicators in immunologic disease states cannot be applied to children in the same manner as adults.

Original languageEnglish (US)
Pages (from-to)341-345
Number of pages5
JournalClinical Immunology and Immunopathology
Volume52
Issue number2
DOIs
StatePublished - Aug 1989

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T-Lymphocyte Subsets
T-Lymphocytes
Fetal Blood
Immune System Diseases
Color
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Cite this

Age-related changes in naive and memory CD4+ T cells in healthy human children. / Pirruccello, Samuel Jay; Collins, Michaeleen; Wilson, Janet E.; McManus, Bruce M.

In: Clinical Immunology and Immunopathology, Vol. 52, No. 2, 08.1989, p. 341-345.

Research output: Contribution to journalArticle

Pirruccello, Samuel Jay ; Collins, Michaeleen ; Wilson, Janet E. ; McManus, Bruce M. / Age-related changes in naive and memory CD4+ T cells in healthy human children. In: Clinical Immunology and Immunopathology. 1989 ; Vol. 52, No. 2. pp. 341-345.
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