Age distribution, polyps and rectal cancer in the egyptian population-based cancer registry

Darlene Veruttipong, Amr S. Soliman, Samuel F. Gilbert, Taylor S. Blachley, Ahmed Hablas, Mohamed Ramadan, Laura S. Rozek, Ibrahim A. Seifeldin

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

AIM: To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS: The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007. All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted: age, residence, diagnosis date, grade, stage, topology, clinical characteristics, and histology variables. Egyptian census data for 1996 and 2006 were used to provide the general population's statistics on age, sex, residence and other related demographic factors. In addition to age- and sex-specific incidence rate analyses, we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the province. We also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results (SEER) data of the United States. RESULTS: Over the 9 year-period, 1364 colorectal cancer cases were included. The disease incidence under age 40 years was relatively high (1.3/105) while the incidence in the age groups 40 and over was very low (12.0/105, 19.4/105 and 21.2/105 in the age groups 40-59 years, 60-69 years and > 70 years, respectively). The vast majority of tumors (97.2%) had no polyps and 37.2% of the patients presented with primary lesions in the rectum. Colorectal cancer was more common in patients from urban (55%) than rural (45%) areas. Regional differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this population. The registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 years. The results also shows significantly lower incidence of colorectal cancer in subjects over age 40 years compared to the same age group in the United States SEER. CONCLUSION: Low rate of polyps, low incidence in older subjects, and high rate of rectal cancer in Egypt. Future studies should explore clinical and molecular disease patterns.

Original languageEnglish (US)
Pages (from-to)3997-4003
Number of pages7
JournalWorld Journal of Gastroenterology
Volume18
Issue number30
DOIs
StatePublished - Dec 28 2012

Fingerprint

Age Distribution
Rectal Neoplasms
Polyps
Registries
Incidence
Colorectal Neoplasms
Population
Neoplasms
Egypt
Age Groups
Epidemiology
Censuses
Population Characteristics
Rectum
Colonic Neoplasms
Medical Records
Histology
Demography

Keywords

  • Colorectal cancer
  • Developing countries
  • Egypt
  • Polyps
  • Young-onset

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Veruttipong, D., Soliman, A. S., Gilbert, S. F., Blachley, T. S., Hablas, A., Ramadan, M., ... Seifeldin, I. A. (2012). Age distribution, polyps and rectal cancer in the egyptian population-based cancer registry. World Journal of Gastroenterology, 18(30), 3997-4003. https://doi.org/10.3748/wjg.v18.i30.3997

Age distribution, polyps and rectal cancer in the egyptian population-based cancer registry. / Veruttipong, Darlene; Soliman, Amr S.; Gilbert, Samuel F.; Blachley, Taylor S.; Hablas, Ahmed; Ramadan, Mohamed; Rozek, Laura S.; Seifeldin, Ibrahim A.

In: World Journal of Gastroenterology, Vol. 18, No. 30, 28.12.2012, p. 3997-4003.

Research output: Contribution to journalArticle

Veruttipong, D, Soliman, AS, Gilbert, SF, Blachley, TS, Hablas, A, Ramadan, M, Rozek, LS & Seifeldin, IA 2012, 'Age distribution, polyps and rectal cancer in the egyptian population-based cancer registry', World Journal of Gastroenterology, vol. 18, no. 30, pp. 3997-4003. https://doi.org/10.3748/wjg.v18.i30.3997
Veruttipong D, Soliman AS, Gilbert SF, Blachley TS, Hablas A, Ramadan M et al. Age distribution, polyps and rectal cancer in the egyptian population-based cancer registry. World Journal of Gastroenterology. 2012 Dec 28;18(30):3997-4003. https://doi.org/10.3748/wjg.v18.i30.3997
Veruttipong, Darlene ; Soliman, Amr S. ; Gilbert, Samuel F. ; Blachley, Taylor S. ; Hablas, Ahmed ; Ramadan, Mohamed ; Rozek, Laura S. ; Seifeldin, Ibrahim A. / Age distribution, polyps and rectal cancer in the egyptian population-based cancer registry. In: World Journal of Gastroenterology. 2012 ; Vol. 18, No. 30. pp. 3997-4003.
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abstract = "AIM: To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS: The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007. All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted: age, residence, diagnosis date, grade, stage, topology, clinical characteristics, and histology variables. Egyptian census data for 1996 and 2006 were used to provide the general population's statistics on age, sex, residence and other related demographic factors. In addition to age- and sex-specific incidence rate analyses, we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the province. We also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results (SEER) data of the United States. RESULTS: Over the 9 year-period, 1364 colorectal cancer cases were included. The disease incidence under age 40 years was relatively high (1.3/105) while the incidence in the age groups 40 and over was very low (12.0/105, 19.4/105 and 21.2/105 in the age groups 40-59 years, 60-69 years and > 70 years, respectively). The vast majority of tumors (97.2{\%}) had no polyps and 37.2{\%} of the patients presented with primary lesions in the rectum. Colorectal cancer was more common in patients from urban (55{\%}) than rural (45{\%}) areas. Regional differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this population. The registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 years. The results also shows significantly lower incidence of colorectal cancer in subjects over age 40 years compared to the same age group in the United States SEER. CONCLUSION: Low rate of polyps, low incidence in older subjects, and high rate of rectal cancer in Egypt. Future studies should explore clinical and molecular disease patterns.",
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AU - Ramadan, Mohamed

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AU - Seifeldin, Ibrahim A.

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N2 - AIM: To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS: The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007. All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted: age, residence, diagnosis date, grade, stage, topology, clinical characteristics, and histology variables. Egyptian census data for 1996 and 2006 were used to provide the general population's statistics on age, sex, residence and other related demographic factors. In addition to age- and sex-specific incidence rate analyses, we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the province. We also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results (SEER) data of the United States. RESULTS: Over the 9 year-period, 1364 colorectal cancer cases were included. The disease incidence under age 40 years was relatively high (1.3/105) while the incidence in the age groups 40 and over was very low (12.0/105, 19.4/105 and 21.2/105 in the age groups 40-59 years, 60-69 years and > 70 years, respectively). The vast majority of tumors (97.2%) had no polyps and 37.2% of the patients presented with primary lesions in the rectum. Colorectal cancer was more common in patients from urban (55%) than rural (45%) areas. Regional differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this population. The registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 years. The results also shows significantly lower incidence of colorectal cancer in subjects over age 40 years compared to the same age group in the United States SEER. CONCLUSION: Low rate of polyps, low incidence in older subjects, and high rate of rectal cancer in Egypt. Future studies should explore clinical and molecular disease patterns.

AB - AIM: To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS: The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007. All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted: age, residence, diagnosis date, grade, stage, topology, clinical characteristics, and histology variables. Egyptian census data for 1996 and 2006 were used to provide the general population's statistics on age, sex, residence and other related demographic factors. In addition to age- and sex-specific incidence rate analyses, we analyze the data to explore the incidence distribution by rural-urban differences among the 8 districts of the province. We also compared the incidence rates of Gharbiah to the rates of the Surveillance Epidemiology and End Results (SEER) data of the United States. RESULTS: Over the 9 year-period, 1364 colorectal cancer cases were included. The disease incidence under age 40 years was relatively high (1.3/105) while the incidence in the age groups 40 and over was very low (12.0/105, 19.4/105 and 21.2/105 in the age groups 40-59 years, 60-69 years and > 70 years, respectively). The vast majority of tumors (97.2%) had no polyps and 37.2% of the patients presented with primary lesions in the rectum. Colorectal cancer was more common in patients from urban (55%) than rural (45%) areas. Regional differences in colon and rectal cancer incidence in the 8 districts of the study province may reflect different etiologic patterns in this population. The registry data of Egypt shows a slightly higher incidence of colorectal cancer than the United States in subjects under age 40 years. The results also shows significantly lower incidence of colorectal cancer in subjects over age 40 years compared to the same age group in the United States SEER. CONCLUSION: Low rate of polyps, low incidence in older subjects, and high rate of rectal cancer in Egypt. Future studies should explore clinical and molecular disease patterns.

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