Advanced soft palate cancer: The clinical importance of the parapharyngeal space

Wade G. Douglas, Nestor R. Rigual, William Giese, Joseph Bauer, Sam M. Wiseman, Thom R. Loree, James Schwarz, Sadir Alrawi, Wesley L. Hicks

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6 Scopus citations

Abstract

OBJECTIVE: To identify the incidence of parapharyngeal space (PPS) recurrences and how they impact survival in advanced-stage soft-palate carcinoma patients. STUDY DESIGN AND SETTING: One hundred thirty-seven patients' charts were reviewed from 1971 to 1996. Inclusion criteria were patients who received a per-oral resection, discontinuous neck dissection, and postoperative adjuvant radiation therapy; 15 patients met criteria for inclusion. The incidence of PPS recurrences, regional failure, and survival were endpoints that were analyzed. RESULTS: There were no local failures in our study. Regional failures excluding the PPS (levels I-V) were 27%, and 40% occurred within the PPS. Cervical adenopathy was associated with 83% of the PPS recurrences. Median survival for PPS recurrences was 26 months, compared with 67 months for levels I-V recurrences (n = ns). CONCLUSIONS: The incidence of PPS recurrences is substantial in advanced-stage soft-palate cancer. PPS recurrences negatively impact survival; without effective salvage techniques for these recurrences or effective adjuvant therapy, poor patient outcomes can be expected.

Original languageEnglish (US)
Pages (from-to)66-69
Number of pages4
JournalOtolaryngology - Head and Neck Surgery
Volume133
Issue number1
DOIs
StatePublished - Jul 2005

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ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Douglas, W. G., Rigual, N. R., Giese, W., Bauer, J., Wiseman, S. M., Loree, T. R., Schwarz, J., Alrawi, S., & Hicks, W. L. (2005). Advanced soft palate cancer: The clinical importance of the parapharyngeal space. Otolaryngology - Head and Neck Surgery, 133(1), 66-69. https://doi.org/10.1016/j.otohns.2005.03.007