Adult Human Mesenchymal Stem Cells Added to Corticosteroid Therapy for the Treatment of Acute Graft-versus-Host Disease

Partow Kebriaei, Luis Isola, Erkut Bahceci, Kent Holland, Scott Rowley, Joseph McGuirk, Marcel P DeVetten, Jan Jansen, Roger Herzig, Michael Schuster, Rod Monroy, Joseph Uberti

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277 Scopus citations

Abstract

The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them a rationale agent to investigate for graft-versus-host disease (GVHD). Human MSCs were used to treat de novo acute GVHD (aGVHD). Patients with grades II-IV GVHD were randomized to receive 2 treatments of human MSCs (Prochymal®) at a dose of either 2 or 8 million MSCs/kg in combination with corticosteroids. Patients received GVHD prophylaxis with tacrolimus, cyclosporine, (CsA) or mycophenolate mofetil (MMF). Study endpoints included safety of Prochymal administration, induction of response to Prochymal, and overall response of aGVHD by day 28, and long-term safety. Thirty-two patients were enrolled, with 31 evaluable: 21 males, 10 females; median age 52 years (range: 34-67). Twenty-one patients had grade II, 8 had grade III, and 3 had grade IV aGVHD. Ninety-four percent of patients had an initial response to Prochymal (77% complete response [CR] and 16% partial response [PR]). No infusional toxicities or ectopic tissue formations were reported. There was no difference with respect to safety or efficacy between the low and high Prochymal dose. In conclusion, Prochymal can be infused safely into patients with aGVHD and induces response in a high proportion of GVHD patients.

Original languageEnglish (US)
Pages (from-to)804-811
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume15
Issue number7
DOIs
StatePublished - Jul 1 2009

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Keywords

  • Allogeneic hematopoietic stem cell transplantation
  • Graft-versus-host disease
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Kebriaei, P., Isola, L., Bahceci, E., Holland, K., Rowley, S., McGuirk, J., DeVetten, M. P., Jansen, J., Herzig, R., Schuster, M., Monroy, R., & Uberti, J. (2009). Adult Human Mesenchymal Stem Cells Added to Corticosteroid Therapy for the Treatment of Acute Graft-versus-Host Disease. Biology of Blood and Marrow Transplantation, 15(7), 804-811. https://doi.org/10.1016/j.bbmt.2008.03.012