Abstract

Burkitt lymphoma is a unique B-cell malignancy with a high proliferation rate and characteristic genetic changes involving the c-myc oncogene. Burkitt lymphoma is common in children but also occurs in adults, where distinction from diffuse large B-cell lymphoma may pose a problem. The development of brief, very intensive chemotherapy regimens has led to a very high cure rate in children with Burkitt lymphoma. The use of these regimens in adults, often in combination with the antibody rituximab (Rituxan), has also made the cure of a majority of adults possible. Burkitt lymphoma in adults cannot be treated effectively with the common regimens used for diffuse large B-cell lymphoma such as CHOP-R (cyclophosphamide, doxorubicin HCl, vincristine [Oncovin], prednisone, rituximab). Prompt diagnosis and initiation of appropriate therapy with attention to the possibility of tumor lysis syndrome are necessary for optimal results.

Original languageEnglish (US)
Pages (from-to)1508-1517
Number of pages10
JournalONCOLOGY
Volume22
Issue number13
StatePublished - Nov 30 2008

Fingerprint

Burkitt Lymphoma
Lymphoma, Large B-Cell, Diffuse
Vincristine
Tumor Lysis Syndrome
myc Genes
Therapeutics
Prednisone
Doxorubicin
Cyclophosphamide
B-Lymphocytes
Drug Therapy
Antibodies
Rituximab
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Adult Burkitt lymphoma : Advances in diagnosis and treatment. / Aldoss, Ibrahim T.; Weisenburger, Dennis D.; Fu, Kai; Chan, Wing C.; Vose, Julie Marie; Bierman, Philip Jay; Bociek, Robert G; Armitage, James Olen.

In: ONCOLOGY, Vol. 22, No. 13, 30.11.2008, p. 1508-1517.

Research output: Contribution to journalArticle

Aldoss IT, Weisenburger DD, Fu K, Chan WC, Vose JM, Bierman PJ et al. Adult Burkitt lymphoma: Advances in diagnosis and treatment. ONCOLOGY. 2008 Nov 30;22(13):1508-1517.
Aldoss, Ibrahim T. ; Weisenburger, Dennis D. ; Fu, Kai ; Chan, Wing C. ; Vose, Julie Marie ; Bierman, Philip Jay ; Bociek, Robert G ; Armitage, James Olen. / Adult Burkitt lymphoma : Advances in diagnosis and treatment. In: ONCOLOGY. 2008 ; Vol. 22, No. 13. pp. 1508-1517.
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