Administration of clozapine to a mother rat potentiates pup ultrasonic vocalization in response to separation and re-separation: Contrast with haloperidol

Ming Li, Wei He, Katherine Heupel

Research output: Contribution to journalArticle

8 Scopus citations


The present study examined how haloperidol (typical) and clozapine (atypical) treatment to mother rats affected their pups' ultrasonic vocalization (USV) response to maternal separation and re-separation (termed " maternal potentiation" ). Clozapine (10. mg/kg, sc) but not haloperidol (0.2. mg/kg, sc) significantly enhanced the maternal potentiation of 40. kHz USVs in pups that were briefly reunited with their dams. This novel paradigm provides an indirect way of assessing the impact of antipsychotic treatment on the quality of maternal care. It may also be useful in examining the impact of antipsychotic treatment on social bonding between infants and mothers.

Original languageEnglish (US)
Pages (from-to)385-389
Number of pages5
JournalBehavioural Brain Research
Issue number2
StatePublished - Sep 23 2011



  • Maternal behavior
  • Maternal potentiation of pup vocalization
  • Maternal separation
  • Pup ultrasonic vocalization
  • Rat

ASJC Scopus subject areas

  • Behavioral Neuroscience

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